ArticleNature biomedical engineering2026
Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales.
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Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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27citing papers in PubMed
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27 citing papers in PubMed.
- Clinical Soma and Neurite Density Imaging (SANDI): Translational Microstructure Mapping on Clinical 3T MRI Scanners.Magnetic resonance in medicine · 2026Article
- Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026Article
- Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.Magnetic resonance in medicine · 2026Article
- Magnetic resonance imaging.Science advances · 2026Review
- Article
- A high-resolution functional network-organized atlas of human superficial white matter from ultra-high-field diffusion MRI.iScience · 2026Article
- Submillimeter postmortem and in vivo diffusion and susceptibility magnetic resonance imaging to characterize cortical micro- and meso-structures.Research square · 2026Article
- Article
- Axon Diameter Mapping From Myelin Water Diffusion MRI.IEEE transactions on medical imaging · 2026Article
- PRIME: Phase reversed interleaved multi-Echo acquisition enables highly accelerated distortion-corrected diffusion MRI.Medical image analysis · 2026Article
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- Human Brain High-Resolution Diffusion MRI With Optimized, Slice-By-Slice, Zeroth and First OrderMagnetic resonance in medicine · 2026Article
- Axon Diameter Mapping in the Living Human Brain with Ultra-High-Gradient Diffusion MRI at 500 mT/m Gradient Strength.Human brain mapping · 2026Article
- Strong-Gradient Diffusion-Weighted Imaging of Prostate Cancer Using an Inside-Out Nonlinear Gradient Coil.Magnetic resonance in medicine · 2026Article
- Bridging the microstructural gap in human connectomics using hierarchical phase-contrast tomography as a reference for diffusion MRI in the human brain.bioRxiv : the preprint server for biology · 2026Article
- What If Each Voxel Were Measured With a Different Diffusion Protocol?Magnetic resonance in medicine · 2026Article
- Did you know? State-of-the-art preprocessing diffusion MRI data can improve tractography.Brain structure & function · 2026Review
- Multi-dimensional diffusion MRI at ultra-high gradient strength for mapping axonal architecture and microstructure in the primate brain.bioRxiv : the preprint server for biology · 2026Article
- Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI.Communications biology · 2026Article
- Cartesian MaxGIRF: Model-based EPI reconstruction incorporating gradient nonlinearity and concomitant field effects.Magnetic resonance in medicine · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
31 authors.
Gabriel Ramos-Llordén *Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA. gramosllorden@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-4020-705X
Hong-Hsi Lee *Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0002-3663-6559
Mathias DavidsAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0003-0217-9123
Peter DietzSiemens Healthineers, Erlangen, Germany.
Andreas KrugSiemens Healthineers, Erlangen, Germany.
John E KirschAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Mirsad MahmutovicInstitute of Medical Physics and Radiation Protection, TH-Mittelhessen University of Applied Sciences, Giessen, Germany.
Alina MüllerInstitute of Medical Physics and Radiation Protection, TH-Mittelhessen University of Applied Sciences, Giessen, Germany.
Yixin MaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Hansol LeeAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Chiara MaffeiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Anastasia YendikiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Berkin BilgicAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Daniel J ParkAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0002-7263-9327
Qiyuan TianAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Bryan CliffordSiemens Medical Solutions USA, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1966-0581
Wei-Ching LoSiemens Medical Solutions USA, Boston, MA, USA.
Stefan StockerSiemens Healthineers, Erlangen, Germany.
Jasmine FischerSiemens Healthineers, Erlangen, Germany.
Gudrun RuytersSiemens Healthineers, Erlangen, Germany.
Manuela RoeslerSiemens Healthineers, Erlangen, Germany.ORCID http://orcid.org/0000-0001-5750-9391
Andreas PotthastSiemens Healthineers, Erlangen, Germany.
Thomas BennerSiemens Healthineers, Erlangen, Germany.
Elmar RummertSiemens Healthineers, Erlangen, Germany.
Rebecca SchusterSiemens Healthineers, Erlangen, Germany.
Peter J BasserEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4795-6088
Thomas WitzelQ Bio Inc., San Carlos, CA, USA.
Lawrence L WaldAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0001-8278-6307
Bruce R RosenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Boris KeilInstitute of Medical Physics and Radiation Protection, TH-Mittelhessen University of Applied Sciences, Giessen, Germany.
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA. susie.huang@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-2950-7254
Funding
CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2MTraining and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Aapo Nummenmaa · 2020 to 2026
$10.9MConnectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across ScalesU24NS137077 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2024 to 2026
$4.0MRevealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRIK99NS132984 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI RAMOS LLORDEN, GABRIEL · 2024 to 2025
$327kDeutsche Forschungsgemeinschaft (German Research Foundation) INST-169/22-1NIBIB NIH HHS P41 EB030006NIBIB NIH HHS U01 EB026996NINDS NIH HHS K99 NS132984NINDS NIH HHS U24 NS137077U.S. Department of Health & Human Services | National Institutes of Health (NIH) DP5-OD031854U.S. Department of Health & Human Services | National Institutes of Health (NIH) P41-EB030006U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01-EB026996U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K99NS132984
Abstract
Defining the connectome, the complete matrix of structural connections between the nervous system nodes, is a challenge for human systems neuroscience due to the range of scales that must be bridged. Here we report the design of the Connectome 2.0 human magnetic resonance imaging (MRI) scanner to perform connectomics at the mesoscopic and microscopic scales with strong gradients for in vivo human imaging. We construct a 3-layer head-only gradient coil optimized to minimize peripheral nerve stimulation while achieving a gradient strength of 500 mT m
Indexed as
BrainConnectomeMagnetic Resonance ImagingHumansWhite Matter
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