Evidence map›Paper›PMID 40670685›Full record

ArticleNature neuroscience2025

Synchronization of visual perception within the human fovea.

Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S Cowan and 4 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Annalisa BucciInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0002-6955-2204
Marc BüttnerInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0001-6940-6656
Niklas DomdeiDepartment of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-9400-8980
Federica B RosselliInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0002-8233-0550
Matej ZnidaricInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0001-5010-6776
Julian BartramDepartment of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0001-7513-1716
Tobias GänsweinDepartment of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0323-6767
Roland DiggelmannDepartment of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1819-0995
Martina De GennaroInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0002-5026-7083
Cameron S CowanInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0003-4262-1182
Wolf HarmeningDepartment of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-7053-1198
Andreas HierlemannDepartment of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0002-3838-2468
Botond RoskaInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.ORCID http://orcid.org/0000-0002-9559-1450
Felix FrankeInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland. felfranke@gmail.com.ORCID http://orcid.org/0000-0001-5550-1222

Funding

Carl-Zeiss-Stiftung (Carl Zeiss Foundation) HC-AOSLODeutsche Forschungsgemeinschaft (German Research Foundation) Ha5323/5-1Deutsche Forschungsgemeinschaft (German Research Foundation) SPP2127 Ha5323/6-1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_220209Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5_173728Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5_216632Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSK-3_221257Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) IC00I0-231344
6 · The paper itself

Abstract

The human brain constructs a model of the world by processing sensory signals with distinct temporal characteristics that may differ in generation and transmission speed within a single sensory modality. To perceive simultaneous events as occurring at the same time, the brain must synchronize this sensory information, yet the mechanisms underlying such synchronization remain unclear. By combining human neural recordings, behavioral measurements and modeling, we show that in the human visual system, this process begins in the fovea centralis, the retinal region used for reading and recognizing faces. Reaction times to foveal single-cone photostimulation were similar across the central visual field, although visual information from neighboring foveal cones travels along axons of highly different lengths. From direct measurements of action potential propagation speeds, axon diameters and lengths in the human fovea centralis, we found that longer foveal axons have larger diameters and increased propagation speeds. We conclude that the human brain orchestrates axonal conduction speeds of unmyelinated axons in the retina to synchronize the arrival times of sensory signals. These results suggest a previously unknown mechanism by which the human brain synchronizes perception.

Indexed as

Fovea CentralisVisual PerceptionAction PotentialsAdultAxonsFemaleHumansMaleModels, NeurologicalPhotic StimulationReaction TimeRetinal Cone Photoreceptor CellsVisual FieldsVisual PathwaysYoung Adult

Identifiers

PMID40670685
PMCPMC12411267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.