SynthesisBreast cancer research and treatment2025
Repeat lumpectomy and external beam radiation therapy for ipsilateral breast cancer recurrence: a systematic review.
Synthesis in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Patterns of Care and Follow-up of Patients with an Ipsilateral Breast Tumor Event After Breast-Conserving Surgery: A Multicenter Retrospective Cohort Study in the Netherlands.Annals of surgical oncology · 2026Observational
- Improved Oncologic Outcomes with Trimodality Therapy for Radiation-Associated Angiosarcoma of the Breast.Annals of surgical oncology · 2026Article
- Salvage treatment strategies for ipsilateral breast tumor recurrence after breast-conserving therapy: a real-world study.The oncologist · 2026Article
- AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2026.Breast care (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSalvage mastectomy is the standard of care for breast cancer patients with ipsilateral breast recurrence (IBR). This systematic review aims to evaluate effectiveness and safety of external beam RT (EBRT) as an accessible modality for repeat BCT.
methodsA systematic literature search was conducted on MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from database inception until September 22, 2024. Clinical studies that investigated the use of second BCT (repeat BCS + post-operative RT) using EBRT were included.
resultsNine articles representing 8 studies and 569 patients were included. Most studies involved patients with T1 disease (6/8 studies, 75%), and node-negative recurrence (5/8 studies, 63%) partial breast re-irradiation was employed in a majority of studies (7/8 studies, 86%). The most common dose-fractionation schedule was 45 Gy in 30 twice-daily fractions (3/8 studies, 37%), followed by 50 Gy in 25 daily fractions (2/8 studies, 25%). The median follow-up ranged from 1.5 to 15 years. The average local recurrence rate was 10%. On average, grade 3 or worse acute and late skin and soft tissue toxicities were 1% and 3%, respectively. Only one study documented the incidence of long-term cardiac mortality (4% of patients) and one reported incidence of second malignancy (3% of patients). None of the included studies assessed patient-reported outcomes using validated quality of life questionnaires.
conclusionRepeat BCT using EBRT is an emerging alternative to salvage mastectomy, offering favourable local control and acceptable rates of treatment-related toxicities.
Indexed as
Identifiers
40670668What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.