ArticleNature plants2025
Trans-organ analysis of gene co-expression networks reveals a mobile long-distance regulator that balances shoot and root development in Arabidopsis.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Harnessing natural variation for photosynthetic improvement in next-generation crop breeding.Journal of integrative plant biology · 2026Review
- Uncovering the early and conserved molecular mechanisms of root nitrogen foraging in model and crops.BMC genomics · 2026Article
- Plant bZIPs in Root Environmental Adaptation: From Single-Cell Expression Atlas to Functional Insights.International journal of molecular sciences · 2026Review
- Metabolomics combined with transcriptomics analysis on ginsenosides accumulation in root of American ginseng plants under foliar applications of brassinolide.Frontiers in plant science · 2026Article
- Integration of ATAC-seq and RNA-seq unveils transcription factors involved in low-nitrogen tolerance in cucumber.Frontiers in plant science · 2026Article
- A mobile transcription factor coordinates systemic responses to nitrogen deficiency.Nature plants · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Long-distance regulation between individual organs is a fundamental process for the optimized adaptation of the plant body to diverse environments. However, systematic methods for identifying key genes for long-distance regulation are currently unavailable. Here we present a new approach, trans-organ analysis of gene co-expression networks, which offers a unique way of identifying candidates for such genes. This approach revealed that TGA7 functions as a shoot-to-root mobile bZIP transcription factor in Arabidopsis to activate photosynthetic genes directly in shoots and nitrate-uptake-related genes, both directly and via a transcriptional cascade, in roots. Analysis of grafted chimeras showed that nitrogen-deficiency-induced enhanced TGA7 expression in shoot vascular tissue promotes TGA7 protein accumulation in roots, boosting root growth and nitrate uptake. Furthermore, the loss of TGA7-mediated long-distance regulation perturbed the balance between shoot and root development under nitrogen deficiency. These findings underscore the utility of our approach for uncovering long-distance regulation in plants.
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