Evidence map›Paper›PMID 40670618›Full record

ArticleNature immunology2025

DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.

Niklas Beumer, Charles D Imbusch, Tamara Kaufmann, Lisa Schmidleithner, Kathrin Gütter, Philipp Stüve, Harriet Marchel, Dieter Weichenhan, Marion Bähr, Brigitte Ruhland and 24 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Engineered CD40-biosensor-expressing Treg cells as a cell therapy approach for inflammatory diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Niklas Beumer *Institute of Immunology, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0001-6538-0217
Charles D Imbusch *Institute of Immunology, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-4920-551X
Tamara Kaufmann *Institute of Immunology, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-4294-8767
Lisa SchmidleithnerLeibniz Institute for Immunotherapy, Regensburg, Germany.
Kathrin GütterLeibniz Institute for Immunotherapy, Regensburg, Germany.
Philipp StüveLeibniz Institute for Immunotherapy, Regensburg, Germany.
Harriet MarchelLeibniz Institute for Immunotherapy, Regensburg, Germany.ORCID http://orcid.org/0009-0000-4242-8505
Dieter WeichenhanDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marion BährDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brigitte RuhlandLeibniz Institute for Immunotherapy, Regensburg, Germany.
Federico MariniResearch Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-3252-7758
Lieke SanderinkLeibniz Institute for Immunotherapy, Regensburg, Germany.
Uwe RitterLeibniz Institute for Immunotherapy, Regensburg, Germany.
Malte SimonFaculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Kathrin Luise BrabandInstitute of Immunology, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-7436-1621
Morten Michael VossInstitute of Immunology, University Medical Center Mainz, Mainz, Germany.
Sara Salome HelbichInstitute of Immunology, University Medical Center Mainz, Mainz, Germany.
Delia Mihaela MihocInstitute of Immunology, University Medical Center Mainz, Mainz, Germany.
Agnes Hotz-WagenblattCore Facility Omics IT and Data Management (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hadrian NassabiDepartment of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Andreas EigenbergerDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
Lukas PrantlDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
Claudia GebhardLeibniz Institute for Immunotherapy, Regensburg, Germany.
Michael RehliLeibniz Institute for Immunotherapy, Regensburg, Germany.ORCID http://orcid.org/0000-0003-3992-932X
Nicholas StriederLeibniz Institute for Immunotherapy, Regensburg, Germany.ORCID http://orcid.org/0000-0003-1183-1099
Kartikeya SinghInstitute of Computational Biology, Helmholtz Munich, Munich, Germany.
Christian SchmidlLeibniz Institute for Immunotherapy, Regensburg, Germany.
Christoph PlassDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jochen HuehnDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0001-8071-1379
Thomas HehlgansLeibniz Institute for Immunotherapy, Regensburg, Germany.
Julia K PolanskyImmuno-Epigenetics, Berlin Institute of Health Center for Regenerative Therapies at Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-4727-2540
Benedikt BrorsDivision of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5940-3101
Michael DelacherInstitute of Immunology, University Medical Center Mainz, Mainz, Germany. delacher@uni-mainz.de.ORCID http://orcid.org/0000-0002-6716-9156
Markus FeuererLeibniz Institute for Immunotherapy, Regensburg, Germany. markus.feuerer@ukr.de.ORCID http://orcid.org/0000-0003-4261-3764

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 318346496 - SFB1292/2 TP19NDeutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 324392634 - TRR 221Deutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 490846870 -TRR355/1 TPA01
6 · The paper itself

Abstract

CD4

Indexed as

DNA MethylationSkinT-Lymphocytes, RegulatoryChromatinDNA Transposable ElementsEpigenesis, GeneticHumansReceptors, Antigen, T-CellChromatinDNA Transposable ElementsReceptors, Antigen, T-Cell

Identifiers

PMID40670618
PMCPMC12307226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.