Evidence map›Paper›PMID 40670616›Full record

Trial reportScientific reports2025

Caffeine reduces accuracy in face recognition memory consolidation.

Candela S Leon, Agustina L Lo Celso, Rocío A Guajardo, Cecilia Forcato

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Candela S LeonLaboratorio de Sueño y Memoria, Departamento de Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Iguazú 341, 1437, Buenos Aires, Argentina.
Agustina L Lo CelsoLaboratorio de Sueño y Memoria, Departamento de Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Iguazú 341, 1437, Buenos Aires, Argentina.
Rocío A GuajardoLaboratorio de Sueño y Memoria, Departamento de Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Iguazú 341, 1437, Buenos Aires, Argentina.
Cecilia ForcatoLaboratorio de Sueño y Memoria, Departamento de Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Iguazú 341, 1437, Buenos Aires, Argentina. cforcato@itba.edu.ar.

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación 02666
6 · The paper itself

Abstract

Numerous studies have shown that caffeine facilitates cognition, particularly memory, when consumed before learning and immediately tested. However, most of this evidence relates to its effects during encoding, and the role in memory consolidation remains unclear. A key study demonstrated that caffeine administered after learning can enhance object recognition memory consolidation by improving discrimination between previously seen targets and similar lures. Here, we investigated the effects of post encoding caffeine on the consolidation of face recognition memory using a randomized, double-blind design. Participants (N = 97) viewed ten generated faces on Day 1 and then received 200 mg of caffeine or placebo. On Day 2, they completed a recognition task under two conditions: Present condition (original face with five similar distractors) or Absent condition (six similar distractors) adding a "none of the above" option. The results showed that, contrary to our expectation, caffeine consumption did not improve the consolidation of face recognition memory. Instead, we observed a general impairment in recognition performance, suggesting a reduced ability to distinguish previously encountered from novel but similar faces. These findings discuss the idea of caffeine as a general cognition enhancer and aligned with studies suggesting it enhances global processing at the expense of detailed discrimination.

Indexed as

CaffeineFacial RecognitionMemory ConsolidationRecognition, PsychologyAdultDouble-Blind MethodFemaleHumansMaleYoung AdultCaffeineCaffeineConsolidationLong-term memoryRecognition memory

Identifiers

PMID40670616
PMCPMC12267838

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.