Evidence map›Paper›PMID 40670579›Full record

ArticleScientific reports2025

Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice.

Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, Stephan Dreschers and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sreepradha EswaranDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Laura GebertDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Sarah SchravenInstitute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Nicole TreichelFunctional Microbiome Research Group, Institute of Medical Microbiology, RWTH Aachen University, Aachen, Germany.
Thomas RitzInstitute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Sabine HammDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Agnes SeegerDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Fabian KiesslingInstitute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Thomas ClavelFunctional Microbiome Research Group, Institute of Medical Microbiology, RWTH Aachen University, Aachen, Germany.
Stephan DreschersDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Norbert WagnerDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany.
Angela SchippersDepartment of Pediatrics, RWTH Aachen University, Aachen, Germany. anschippers@ukaachen.de.ORCID http://orcid.org/0000-0003-2132-7486

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction associated steatotic liver disease (MASLD) presents a growing global health problem. Disease progression is promoted not only by hepatic leukocyte accumulation but also by inflammatory signals from adipose tissue and an altered gut microbiome. To determine the contribution of intercellular adhesion molecule-1 (ICAM-1) to MASLD pathogenesis, male mice with an ICAM-1 mutation (Icam1

Indexed as

Adipose TissueDiet, WesternFatty LiverInflammationInsulin ResistanceIntercellular Adhesion Molecule-1Adipose Tissue, WhiteAnimalsGastrointestinal MicrobiomeLiverMaleMiceMice, Inbred C57BLIcam1 protein, mouseIntercellular Adhesion Molecule-1ICAM-1MASLDMetabolic syndromeMicrobiomeSteatohepatitisWestern diet

Identifiers

PMID40670579
PMCPMC12267403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.