ArticleScientific reports2025
Antimicrobial activity of new glycoside derivatives of chloroflavones obtained by fungal biotransformation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Developmental stage-dependent changes in kaempferol derivatives and associated antioxidant, antibacterial, and quorum sensing inhibitory activities inFood chemistry: X · 2026Article
- Descriptions of Four New Species in Cunninghamellaceae (Mucoromycota) from the Brazilian Savanna Through Integrative Taxonomy.Journal of fungi (Basel, Switzerland) · 2026Article
- Purification and characterization of a dihydroxy Oxocyclohexyl acetate derivative from endophytic Aspergillus Candidus targeting Candida albicans lanosterol 14α-Demethylase.Scientific reports · 2026Article
- Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Chlorinated flavonoids represent a unique subclass of flavonoids with chlorine substituents. The incorporation of chlorine atoms and glucosyl moieties may influence their bioavailability, bioactivity, and pharmacological potential. In this study, 2'-chloroflavone, 3'-chloroflavone, 4'-chloroflavone, and 6-chloroflavone were synthesized and biotransformed using entomopathogenic fungi cultures (Isaria fumosorosea KCH J2 and Beauveria bassiana KCH J1.5) to obtain novel glycosylated derivatives. Pharmacokinetic properties and drug-likeness were predicted using cheminformatics tools. Antimicrobial activity was evaluated against several microbial strains. Enterococcus faecalis ATCC 19433 showed complete growth inhibition with 4'-chloroflavone and 6-chloroflavone, while 2'-chloroflavone and 3'-chloroflavone significantly inhibited its growth. Flavonoid glycosides and flavone demonstrated lower efficacy. Staphylococcus aureus ATCC 29213 was completely or strongly inhibited by all tested compounds. Lactobacillus acidophilus ATCC 4356 was moderately inhibited by flavonoid aglycones and slightly inhibited by glycosides. Escherichia coli ATCC 25922 was most effectively inhibited by 4'-chloroflavone and 6-chloroflavone, followed by 2'-chloroflavone and 3'-chloroflavone, with flavone and glycosides showing lower activity. Candida albicans ATCC 1023 exhibited high sensitivity to all compounds. Overall, chlorinated flavones demonstrated greater antimicrobial activity than non-chlorinated counterparts, with aglycones being more effective than glycosylated derivatives. The position of the chlorine atom significantly influences antimicrobial activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.