Evidence map›Paper›PMID 40670486›Full record

Trial reportScientific reports2025

Measuring mitochondrial oxygenation and respiration during systemic inflammation in humans in vivo.

Mark A Wefers Bettink, Jelle Zwaag, Bernard Schockaert, Peter Pickkers, Matthijs Kox, Egbert G Mik

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark A Wefers BettinkDepartment of Anesthesiology laboratory of experimental anesthesiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jelle ZwaagRadboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Bernard SchockaertDepartment of Anesthesiology laboratory of experimental anesthesiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peter PickkersRadboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Matthijs KoxRadboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Egbert G MikDepartment of Anesthesiology laboratory of experimental anesthesiology, Erasmus University Medical Center, Rotterdam, The Netherlands. e.mik@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbances in mitochondrial function are implicated in several chronic and acute diseases. Systemic inflammation has been described to affect mitochondrial respiration. Yet, in vivo measurement of mitochondrial respiration is notoriously difficult. We measured mitochondrial oxygen tension (mitoPO

Indexed as

InflammationMitochondriaOxygenOxygen ConsumptionAdultCell RespirationHumansLipopolysaccharidesMaleYoung AdultLipopolysaccharidesOxygen5-aminolevulinic acidEndotoxemiaHealthy volunteersLipopolysaccharidesMitochondria

Identifiers

PMID40670486
PMCPMC12267839

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.