ArticleNature communications2025
Small RNA in sperm-Paternal contributions to human embryo development.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- qMAP decodes RNA fragmentation dynamics in development and disease.Molecular systems biology · 2026Article
- Heat Stress and the Bull Sperm Transcriptome: Molecular Mechanisms, Fertility, and Epigenetic Inheritance.Animals : an open access journal from MDPI · 2026Review
- Non-Coding RNA Biomarkers in Male Infertility: From Discovery to Clinical Actionability-A Narrative Review.Genes · 2026Review
- A modular class-aware workflow for small RNA sequencing analysis using mouse sperm as a case study.Epigenomics · 2026Article
- Sperm 28S ribosomal RNA fragments as a potential biomarker for embryo quality in in vitro fertilization.Journal of assisted reproduction and genetics · 2026Article
- Epididymosome-Supplemented Extender Induces Changes in Morpho-Functional Traits and microRNA Levels of Post-Thaw Sperm and Improves Embryo Developmental Potential.Molecular reproduction and development · 2026Article
- Influence of sire fertility on the metabolism of in vitro produced embryos.Reproduction & fertility · 2026Article
- Cumulus cell DNA fragmentation in relation to oocyte yield and blastocyst quality.Reproduction & fertility · 2026Article
- Sex-specific associations between psychological resilience and blastocyst quality.Reproduction & fertility · 2026Observational
- Efficacy and safety of a one-step warming protocol of vitrified blastocyst stage embryos.F&S reports · 2026Article
- Environmentally-induced sperm RNAs shape placentation and fetal growth.Research square · 2026Article
- When sperm age, their RNA code hits a cliff.The EMBO journal · 2026Article
- Article
- Clinical Implications of Paternal Age in Assisted Reproduction: Integrating Sperm Epigenetic Evidence.Journal of clinical medicine · 2026Review
- Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging.The EMBO journal · 2026Article
- Sperm TLR2/1 activation modulates the paternal RNA cargo and enhances bovine embryonic development.Frontiers in physiology · 2026Article
- Antibiotics administration during weaning ameliorates intestinal mucosal inflammation in adult mice and their offspring.Frontiers in immunology · 2026Article
- tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis.Journal of Cancer · 2026Review
- The efficacy of ionomycin - induced artificial oocyte activation in preventing fertilization failure in an ICSI cycle: an eight - year retrospective study.Journal of ovarian research · 2025Article
- Gene regulation by non-Coding RNAs in infertility: a mechanistic review.Journal of ovarian research · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Sperm not only delivers the paternal genome to the oocyte but also regulatory small RNA (sRNA). However, the role of sRNA in fertilisation and human embryo development remains poorly understood. Here, couples undergoing IVF are recruited, and sperm sRNA analysed to investigate their role in IVF treatment. Differential expression of mitochondrial sRNA and Y-RNA are observed in relation to sperm concentration. For fertilisation rate, sRNA from a single locus are significantly changed. Expression of microRNA (miRNA) and ribosomal sRNA correlates positively and negatively, respectively, to high-quality embryos. Notably, the top miRNA have an area under ROC of >0.8. Predicted targets of these miRNA are relevant for development, suggesting a role for sperm-borne miRNA in embryo development. In conclusion, sperm-borne sRNA are biomarkers for sperm concentration and embryo quality in IVF. These findings may contribute to clinical strategies improving embryo quality, lowering costs and reducing the need for additional treatment cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.