ArticleRenal failure2025
Preoperative long-term use of renin-angiotensin-aldosterone system blockers increases the risk of acute kidney injury after coronary artery bypass grafting.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThe effect of preoperative renin-angiotensin-aldosterone system (RAAS) blockers on acute kidney injury (AKI) after cardiac surgery remains controversial. This study aimed to evaluate the effect of long-term RAAS blocker use on AKI incidence following coronary artery bypass grafting (CABG).
methodsPatients undergoing CABG were included in this retrospective cohort study and divided into control group and medication group. The primary outcome was AKI, while secondary outcomes included the initiation of renal replacement therapy, duration of intensive care unit and total hospitalization, invasive ventilation time, and intraoperative blood pressure conditions. Propensity score matching (PSM) was used to correct for imbalances in baseline characteristics between the groups. Lasso regression and multivariate logistic regression were employed to control for confounding factors and to validate the correlation between medication and AKI. Subgroup and interaction analyses were conducted to examine the heterogeneity of the effect across subgroups. Finally, mediation effect analysis was used to explore potential mechanisms and pathways.
resultsA total of 317 patients were included in the study, with 184 in the control group and 133 in the medication group. After PSM, matched cohorts were achieved. The medication group had a higher AKI incidence (24.8% versus 10.5%,
conclusionPreoperative long-term use of RAAS blockers significantly increases the risk of AKI in patients undergoing CABG.
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