Evidence map›Paper›PMID 40670291›Full record

ReviewAnnual review of neuroscience2025

Synaptic Vesicle Recycling Through the Lens of Ultrafast Endocytosis.

Shigeki Watanabe

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Molecular Physiology of the Neuronal Synapse.Current issues in molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Shigeki WatanabeDepartment of Cell Biology and Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; email: shigeki.watanabe@jhmi.edu.

Funding

Ultrafast membrane trafficking at synapsesR35NS132153 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Shigeki Watanabe · 2023 to 2026
$4.1M
Reviving electron microscopy for synaptic cell biologyDP2NS111133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2018
$2.5M
Spatial and molecular determinants of fusion probability and timingR01NS105810 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2022
$1.8M
NINDS NIH HHS DP2 NS111133NINDS NIH HHS R01 NS105810NINDS NIH HHS R35 NS132153
6 · The paper itself

Abstract

The mechanisms underlying synaptic vesicle endocytosis remain controversial. In the 1970s, Heuser and Reese put forward a hypothesis that clathrin-mediated endocytosis is the predominant vesicle retrieval mechanism. In their seminal papers, another pathway was also described: uncoated large vesicles or cisternae emanating from the plasma membrane 1 s after a single stimulus. This pathway likely represents a recently described ultrafast endocytic pathway that recovers synaptic vesicles during physiological stimuli. Had we known of the existence of ultrafast endocytosis or paid more attention to the cisternae-based uptake pathway, would the experimental results over subsequent years have been interpreted differently? Here, I retrospectively review the literature on synaptic vesicle recycling through the lens of ultrafast endocytosis.

Indexed as

EndocytosisSynaptic VesiclesAnimalsHumansSynaptic Transmissionactivity-dependent bulk endocytosisclathrin-mediated endocytosiskiss-and-runsynaptic vesicle endocytosissynaptic vesicle recyclingultrafast endocytosis

Identifiers

PMID40670291
PMCPMC12536329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.