Evidence map›Paper›PMID 40670154›Full record

ArticleRNA (New York, N.Y.)2025

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2.

Paul A Wagner, Meimei Song, Paul Doran, Ayşenur Şeker, Ralf Ficner, Bernhard Kuhle, Assen Marintchev

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Structural basis for non-AUG translation regulation by 5MPs.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Paul A WagnerDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Meimei SongDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Paul DoranDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Ayşenur ŞekerDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Ralf FicnerDepartment of Molecular Structural Biology, GZMB, University of Göttingen, 37077 Göttingen, Germany.
Bernhard KuhleDepartment of Molecular Biology, University Medical Center Göttingen, 37073 Göttingen, Germany bernhard.kuhle@med.uni-goettingen.de amarint@bu.edu.
Assen MarintchevDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA bernhard.kuhle@med.uni-goettingen.de amarint@bu.edu.ORCID 0000-0002-9901-3500

Funding

Mechanisms of action of human translation initiation factors and their regulationR01GM134113 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MARINTCHEV, ASSEN G · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM134113
6 · The paper itself

Abstract

The heterotrimeric GTPase eukaryotic translation initiation factor 2 (eIF2) delivers the initiator Met-tRNA

Indexed as

Casein Kinase IIEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BEukaryotic Initiation Factor-5Eukaryotic Initiation FactorsSaccharomyces cerevisiae ProteinsBinding SitesCrystallography, X-RayEukaryotic Translation Initiation Factor 5AHumansModels, MolecularProtein BindingSaccharomyces cerevisiaeCasein Kinase IIEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BEukaryotic Initiation Factor-5Eukaryotic Initiation FactorsEukaryotic Translation Initiation Factor 5ASaccharomyces cerevisiae ProteinsCK2integrated stress responseNMRprotein structuretranslation initiationX-ray crystallography

Identifiers

PMID40670154
PMCPMC12439599

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.