Evidence map›Paper›PMID 40670073›Full record

ArticleNeurosciences (Riyadh, Saudi Arabia)2025

Poloxamer 188 alleviates cerebral ischemia-reperfusion injury in mice by reducing mitochondrial and lysosomal membrane damage.

Hui Xu, Zhanhu Zhang, Xiaodong Tao, Ruirui Shi, Jian Xu, Xiaohua Zhang, Jinhua Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosciences (Riyadh, Saudi Arabia), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui XuFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Zhanhu ZhangFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Xiaodong TaoFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Ruirui ShiFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Jian XuFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Xiaohua ZhangFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
Jinhua GuFrom Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-5177-8352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the beneficial effects and mechanisms of Poloxamer 188 (P188) in mitigating cerebral ischemia-reperfusion (I/R) injury in mice.

methodsThis study was conducted from 2020 to 2022. Neurological function, brain water content, and infarct size were assessed in mice 24 h after I/R injury. Iridium-labeled Poloxamer 188 (Ir-P188) was characterized using

resultsP188 intravenous administration could significantly reduce the infarct brain areas, improved neurological deficit, and decreased brain water content in mice after I/R injury. The accumulation of Ir-P188 was observed in OGD/R-induced HT22 cells and ischemic brain in mice. P188 suppressed ROS, inflammatory factors (NF-kB, IL-6, TNF-a), and inhibiting mitochondrial cytochrome C release and lysosomal protease translocation to the cytoplasm.

conclusionP188 can penetrate intracellular compartments and effectively protect mice against I/R injury. The underlying mechanism may involve inhibiting ROS generation, mitigating inflammatory responses, and alleviating mitochondrial dysfunction and lysosomal damage.

Indexed as

Brain IschemiaLysosomesMitochondriaNeuroprotective AgentsPoloxamerReperfusion InjuryAnimalsMaleMiceNeuroprotective AgentsPoloxamer

Identifiers

PMID40670073
PMCPMC12279340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.