Evidence map›Paper›PMID 40669910›Full record

ArticleBMJ open2025

Inhalational nitrous oxide as a transdiagnostic approach for the treatment of suicidal ideation and suicidality in psychiatric inpatients: protocol for a double-blind randomised, controlled clinical single-centre trial.

Golo Kronenberg, Anna Bankwitz, Barbora Provaznikova, Mario Müller, Boris B Quednow, Erich Seifritz, Sebastian Olbrich

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06636357 (Nitrous Oxide in the Treatment of Acute Suicidal Ideation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06636357 phase2recruitingnot on this map

Nitrous Oxide in the Treatment of Acute Suicidal Ideation

TypeinterventionalSponsorUniversity of ZurichRan2025 to 2026Enrolled85ConditionsSuicidality, EEG, Suicidal Ideation, Nitrous OxideArms50% N2O plus 50% O2, Oxygen (O2)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Golo KronenbergDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland golo.kronenberg@pukzh.ch.ORCID http://orcid.org/0000-0002-5310-9849
Anna BankwitzDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Barbora ProvaznikovaDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Mario MüllerDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Boris B QuednowDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Erich SeifritzDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Sebastian OlbrichDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSuicidal thoughts and behaviours are linked to a wide range of mental health conditions. New interest in the psychiatric benefits of nitrous oxide (N METHODS AND ANALYSIS: This is the protocol of a single-centre pilot study of N ETHICS AND DISSEMINATION: This study was approved by the local ethics committee ('Kantonale Ethikkommission-Kanton Zürich') and by the Swiss Agency for Therapeutic Products (Swissmedic). Study results will be disseminated primarily by peer-reviewed scientific journals and also by conference presentations, patient and public events and social media. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID NCT06636357.

Indexed as

Mental DisordersNitrous OxideSuicidal IdeationAdministration, InhalationAdultDouble-Blind MethodFemaleHumansInpatientsMaleMiddle AgedPilot ProjectsRandomized Controlled Trials as TopicNitrous OxideCLINICAL PHARMACOLOGYDepression & mood disordersPsychometricsSuicide & self-harm

Identifiers

PMID40669910
PMCPMC12273121

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.