Evidence map›Paper›PMID 40669903›Full record

SynthesisBMJ open2025

Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review.

Anastasia Hughes, Angela Ju, Rosanna Cazzolli, Martin Howell, Chandana Guha, Adeera Levin, Karine Manera, Armando Teixeira-Pinto, Luca G Torrisi, David C Wheeler and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anastasia HughesSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia anastasia.hughes@sydney.edu.au.ORCID http://orcid.org/0009-0003-5512-0333
Angela JuSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Rosanna CazzolliSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Martin HowellSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9740-712X
Chandana GuhaSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0767-4185
Adeera LevinDivision of Nephrology, The University of British Columbia, Vancouver, British Columbia, Canada.
Karine ManeraSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0552-6074
Armando Teixeira-PintoSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Luca G TorrisiSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
David C WheelerDepartment of Renal Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0003-0745-3478
Germaine WongSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Rebecca WuSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Allison JaureSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8973-9538

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFatigue is a common and debilitating symptom that is associated with an increased risk of mortality, dialysis initiation and hospitalisation among patients with chronic kidney disease (CKD). The aim of this study was to identify the characteristics, content and psychometric properties of patient-reported outcome measures (PROMs) used to measure fatigue in patients with CKD not requiring kidney replacement therapy (KRT).

designSystematic review. The characteristics, dimensions of fatigue and psychometric properties of these measures were extracted and analysed. DATA SOURCES: We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: All studies that reported fatigue in patients with CKD stages 1-5 not receiving KRT.

resultsWe identified 97 studies (20 (21%) randomised trials, 2 (2%) non-randomised trials and 75 (77%) observational studies). 27 different measures were used to assess fatigue, of which three were author-developed measures. The 36-Item Short Form Health Survey (SF-36) and Kidney Disease Quality of Life - Short Form (KDQOL-SF) were the most frequently used measures (41 (42%) and 24 (25%) studies, respectively). Six (22%) measures were specific to fatigue (Chalder Fatigue Questionnaire, Functional Assessment of Chronic Illness Therapy - Fatigue Scale, Functional Assessment of Cancer Therapy-Fatigue, Fatigue Severity Scale, and author developed Chen & Ku 1998, and Hao

conclusionPROMs used to assess fatigue in patients with CKD vary in content and few were specific to fatigue in patients with CKD not requiring KRT. Data to support the psychometric robustness of PROMs for fatigue in CKD were sparse. A validated and content-relevant measure to assess fatigue in patients with CKD is needed.

Indexed as

FatiguePatient Reported Outcome MeasuresRenal Insufficiency, ChronicHumansPsychometricsQuality of LifeChronic renal failureFatigueNEPHROLOGYPatient Reported Outcome MeasuresQuality of Life

Identifiers

PMID40669903
PMCPMC12273140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.