Evidence map›Paper›PMID 40669707›Full record

ArticleJournal of affective disorders2025

Pathways to better sleep: Depression, anxiety, and stress as mediators in the relationship between social support and insomnia severity in Appalachian adults.

Mairead E Moloney, Emily Slade, Joon Chung, Kory Heier, Daniela C Moga

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Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mairead E MoloneyUniversity of Miami, Miller School of Medicine, Department of Informatics and Health Data Science, United States of America; University of Miami, Frost Institute for Data Science and Computing, United States of America. Electronic address: memoloney@miami.edu.
Emily SladeUniversity of Kentucky, College of Public Health, Department of Biostatistics, United States of America.
Joon ChungUniversity of Miami, Miller School of Medicine, Department of Informatics and Health Data Science, United States of America.
Kory HeierUniversity of Kentucky, College of Public Health, Department of Biostatistics, United States of America.
Daniela C MogaUniversity of Kentucky, College of Pharmacy, Department of Pharmacy Science and Practice, United States of America.

Funding

Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars: Dr. ConnerK12DA035150 · NIDA · UNIVERSITY OF KENTUCKY · PI Thomas E Curry · 2012 to 2026
$9.0M
Sleeping well in a changing climate: The effects of rising temperatures and extreme weather events on sleep and other aspects of health in rural AppalachiaR01MD016236 · NIMHD · UNIVERSITY OF KENTUCKY · PI MOGA, DANIELA CLAUDIA, MOLONEY, MAIREAD · 2021 to 2025
$4.1M
NIDA NIH HHS K12 DA035150NIMHD NIH HHS R01 MD016236
6 · The paper itself

Abstract

backgroundRural Appalachia has some the highest rates of sleep and health disparities in the United States. This study investigates the relationship between social support and insomnia severity in rural Appalachian adults, with specific attention to the potential mediating roles of depression, anxiety, and stress.

methodsParticipants from 12 rural Eastern Kentucky counties completed validated measures of insomnia severity, social support, depression, anxiety, and perceived stress. Using R, we calculated descriptive statistics and fit mediation models for depressive symptoms, anxiety symptoms, and stress, with social support as the exposure and insomnia severity as the outcome.

resultsAligning with regional demographics, nearly all participants identified as Caucasian/White (97.4 %) and non-Hispanic/non-Latin (a/o)/non-Latinx (96.8 %). Of 270 participants (mean age: 46 [SD = 13.2], 79.9 % women) 30 % had clinically significant insomnia. Greater social support was associated with lower insomnia severity (r = -0.30, p < 0.001) in unadjusted analyses. Mediation analyses revealed that this relationship was significantly mediated by depressive symptoms (69 %), anxiety symptoms (64 %), and perceived stress (78 %). After accounting for these psychological mediators, the direct effect of social support on insomnia was no longer significant.

conclusionsOur findings provide valuable insight into the psychological mechanisms linking social support and sleep health in rural Appalachian adults, though generalizability may be limited to similar racially homogeneous, rural populations. Social support influences insomnia symptoms in rural Appalachian adults primarily through psychological pathways, particularly by buffering against stress. Interventions addressing sleep problems in this population should target psychological factors while leveraging existing social resources within the cultural context of Appalachia.

Indexed as

AnxietyDepressionSleep Initiation and Maintenance DisordersSocial SupportStress, PsychologicalAdultAgedAppalachian RegionFemaleHumansKentuckyMaleMiddle AgedRural PopulationSeverity of Illness IndexAnxietyDepressionInsomniaSocial supportStress

Identifiers

PMID40669707
PMCPMC12356612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.