Imaging techniques for the detection of choroidal neovascularization.

Mi Zheng, Yannis M Paulus

Abstract readReview

In one paragraph

Review in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mi ZhengDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA; Department of Ophthalmology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, 350001, China; Department of Ophthalmology, Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 350001, China. Electronic address: mzheng30@jh.edu.

Yannis M PaulusDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21287, USA. Electronic address: ypaulus1@jh.edu.

Funding

Multimodal Molecular Imaging of Choroidal NeovascularizationR01EY034325 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yannis Mantas Paulus, XUEDING WANG · 2023 to 2026

$2.5M

Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug DeliveryR01EY033000 · NEI · PURDUE UNIVERSITY · PI LEE, CHI HWAN, PAULUS, YANNIS MANTAS · 2021 to 2025

$1.9M

NEI NIH HHS R01 EY033000NEI NIH HHS R01 EY034325

6 · The paper itself

Abstract

Choroidal neovascularization (CNV) has been associated with a wide variety of chorioretinal disorders, which can cause vascular leakage, bleeding, and scar formation, leading to significant vision loss. The effective and precise detection of CNV is essential for optimal disease management. A classification system has been devised to categorize neovascularization according to its anatomical location. The system distinguishes three distinct types of neovascularization: type 1, type 2, and type 3. According to the exudative features of the new vessels, CNV can be divided into exudative and non-exudative categories. Each type of CNV exhibits unique features across various imaging modalities. The present study reviews contemporary imaging modalities employed in the detection of CNV, with a focus on the underlying mechanisms, their respective advantages and disadvantages, their typical clinical utilization, and the characteristic features of CNV that are discernible through these techniques. The exploration of novel promising imaging techniques for CNV detection including photoacoustic microscopy, AI, photothermal OCT, and functional fluorescent angiography is also performed.

Indexed as

ChoroidChoroidal NeovascularizationFluorescein AngiographyTomography, Optical CoherenceFundus OculiHumansPhotoacoustic TechniquesChoroidal neovascularizationFluorescein angiographyFunctional fluorescein isothiocyanateImaging techniquesIndocyanine green angiographyOptical coherence tomographyOptical coherence tomography angiographyPhotoacoustic microscopyPhotothermal OCT

Identifiers

PMID40669688

DOI10.1016/j.exer.2025.110522

PMCPMC12301546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.