Evidence map›Paper›PMID 40669300›Full record

ArticleMaturitas2025

Incidence of de novo migraine after premenopausal bilateral oophorectomy.

Samantha E Mannion, Carin Y Smith, Jennifer A Buzzard, Liliana Gazzuola Rocca, Jennifer St Sauver, Walter A Rocca, Ekta Kapoor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maturitas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Neurology of Menopause.Current neurology and neuroscience reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha E MannionWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of General Internal Medicine, Northwestern University, 420 E Superior St, Chicago, IL 60611, United States. Electronic address: Samantha.Mannion@nm.org.
Carin Y SmithDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Smith.Carin@mayo.edu.
Jennifer A BuzzardWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Buzzard.Jennifer@mayo.edu.
Liliana Gazzuola RoccaDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.
Jennifer St SauverDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: StSauver.Jennifer@mayo.edu.
Walter A RoccaWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Rocca@mayo.edu.
Ekta KapoorWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Center for Women's Health, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Kapoor.Ekta@mayo.edu.

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Reproductive risk factors for Alzheimer's disease dementia and pathologyRF1AG055151 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M, ROCCA, WALTER A · 2017 to 2017
$4.0M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS R33 AG058738NIA NIH HHS RF1 AG055151NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

objectiveLittle is known about the effects of premenopausal bilateral oophorectomy on the development of migraine. We compared migraine outcomes for women undergoing oophorectomy with those of referent women. STUDY

designThe cohort included 1243 women who underwent premenopausal bilateral oophorectomy in Olmsted County, MN, US between 1988 and 2007 and 1415 age-matched (±1 year) referent women. Women diagnosed with migraine before oophorectomy (or index) were excluded. Estrogen therapy after oophorectomy was assessed as a time-dependent factor.

resultsWomen who underwent oophorectomy had an increased risk of de novo migraine compared with referent women (HR, 1.59; 95 % CI, 1.24-2.05). The risk was particularly higher for women who underwent oophorectomy under the age of 45 years. An increased risk of migraine without aura, but not of migraine with aura, was observed, as is characteristic of menstrual migraines. The risk of de novo migraine in the women with oophorectomy off estrogen was comparable to that of the referent women (HR, 0.80; 95 % CI, 0.43-1.52). By contrast, women with oophorectomy on estrogen had an increased risk of migraine (HR, 2.08; 95 % CI, 1.47-2.92).

conclusionsPremenopausal bilateral oophorectomy is associated with an increased risk of migraine. Although estrogen is known to mitigate the severity of menopause-related symptoms, the higher risk for migraine among women using estrogen could be the result of them being prescribed estrogen because of greater severity of menopause symptoms. We encourage future studies to examine how the type, dose, and route of estrogen impact migraine outcomes after oophorectomy.

Indexed as

Estrogen Replacement TherapyMigraine DisordersOvariectomyPremenopauseAdultCase-Control StudiesCohort StudiesEstrogensFemaleHumansIncidenceMiddle AgedMigraine with AuraMigraine without AuraMinnesotaRisk FactorsEstrogensBilateral oophorectomyEarly menopauseEstrogenIatrogenic menopauseMigraine headachePremature menopause

Identifiers

PMID40669300
PMCPMC12309069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.