Trial reportEBioMedicine2025
Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans.
Trial report in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Intensity-dependent lipidomic dynamic regulation following acute swimming exercise.Scientific reports · 2026Trial
- Strenuous Exercise and Quercetin Supplementation Differentially Alter Lipid Metabolism in C57BL/6J Mice.Journal of lipid and atherosclerosis · 2026Article
- Metabolomic and Proteomic Signatures of Cardiorespiratory Fitness for Predicting All-Cause Mortality and Non-Communicable Disease Risk: A Prospective Study in the UK Biobank.Circulation. Genomic and precision medicine · 2026Article
- Deciphering the circulating lipidome signature associated with physical performance in gastric cancer patients: an exploratory study.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.Lipids in health and disease · 2026Article
- Walking handball as an exercise alternative to conventional walking and recreational team handball.Frontiers in sports and active living · 2026Article
- Causal Relationships Among Lifestyle, Lipidome, and Polycystic Ovary Syndrome: A Mendelian Randomization Study.International journal of women's health · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegular physical exercise shows significant health-related benefits, potentially through the modulation of lipid metabolism in an intensity-dependent manner.
methodsIn this study, we profiled 794 plasma lipid species across 18 subclasses following a 24-week supervised concurrent and randomised exercise intervention at moderate and vigorous intensities in 101 young, sedentary adults.
findingsHere, we demonstrate that moderate-intensity exercise, but not vigorous-intensity, significantly increased plasma levels of glycerophospholipids and triacylglycerol species. Interestingly, we also identified a sex-specific response to moderate-intensity exercise, with men exhibiting elevated glycerophospholipids and lysophospholipids species, and women showing significant increases in triacylglycerols species. Increments in glycerophospholipids species were associated with improvements in cardiorespiratory fitness, i.e., VO
interpretationImportantly, while traditional lipid markers, including total cholesterol or triglycerides remained unchanged after the exercise intervention, our findings suggest that exercise partially exerts its health benefits by selectively targeting and modifying specific lipid subtypes in an intensity, sex-dependent manner.
fundingThe study was supported by the Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento (ref. P18-RT-4455, ref. SOMM17/6107/UGR, and DOC 01151) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), and PTA-12264, Retos de la Sociedad (DEP2016-79512-R), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES).
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