ArticleBiochemistry2025
Coenzyme A Tethering Mediates Dehydratase Substrate Promiscuity and Reaction Specificity in Platensimycin, Platencin, and Platensilin Biosynthesis.
Lucas L Fluegel, Andrew D Steele, Edward Kalkreuter, Chun Gui, Dong Yang, Ben Shen
Abstract read
In one paragraphArticle in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Lucas L FluegelDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.
Andrew D SteeleDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.ORCID 0000-0002-1252-1992 Edward KalkreuterDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.
Chun GuiDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.ORCID 0000-0002-2945-5856 Dong YangDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.ORCID 0000-0003-2917-0663 Ben ShenDepartment of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, United States.ORCID 0000-0002-9750-5982 Funding
Mining Actinomycetal Genomes for Natural Product Discovery and BiosynthesisR35GM134954 · NIGMS · UNIVERSITY OF FLORIDA · PI Ben Shen · 2020 to 2026
$5.1MBruker Avance III HD 600 MHz NMR spectrometerS10OD021550 · OD · SCRIPPS FLORIDA · PI KOJETIN, DOUGLAS · 2017 to 2017
$600kBiosynthesis of the Leinamycin Family of Natural Products: Mechanistic Studies and Chemoenzymatic Analog SynthesisF32GM133114 · NIGMS · UNIVERSITY OF FLORIDA · PI STEELE, ANDREW · 2019 to 2021
$195kCharacterization of the Thioacid Biosynthetic Machinery and Isolation of a Novel Thioacid Enediyne Natural ProductF32GM134688 · NIGMS · UNIVERSITY OF FLORIDA · PI KALKREUTER, ROBERT EDWARD · 2019 to 2021
$192kNIGMS NIH HHS F32 GM133114NIGMS NIH HHS F32 GM134688NIGMS NIH HHS R35 GM134954NIH HHS S10 OD021550
6 · The paper itselfAbstract
Biosynthetic studies of the platensimycin (PTM), platencin (PTN), and platensilin (PTL) family of natural products have revealed numerous insights into the chemistry and enzymology of diterpenoid biosynthesis. A deeper understanding of the PTM biosynthetic machinery would advance fundamental knowledge in natural product biosynthesis and facilitate future efforts to exploit these compounds as potential leads for biomedical applications. Herein, we report the functional characterization of the
Indexed as
AdamantaneAminobenzoatesAminophenolsAnilidesBacterial ProteinsCoenzyme AHydro-LyasesPolycyclic CompoundsKineticsMolecular Docking SimulationStreptomycesSubstrate SpecificityAdamantaneAminobenzoatesAminophenolsAnilidesBacterial ProteinsCoenzyme AHydro-LyasesplatencinplatensimycinPolycyclic Compounds
Identifiers
PMID40668985
PMCPMC12746908
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