ArticleThe Journal of infectious diseases2026
Elimination of Human Immunodeficiency Virus Reservoirs Harboring Intact Proviruses.
Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Selective elimination of myeloid HIV reservoirs by targeting pro-survival pathways.The Journal of infection · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundHuman immunodeficiency virus (HIV) establishes persistent infection by integrating its proviral DNA into the host genome. While most integrated proviruses are defective, a small portion of proviruses are intact that represent a major obstacle to achieving an HIV cure. We have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules during viral reactivation. However, the effects of SECH on the dynamics of intact and defective HIV provirus remain unclear.
methodsWe isolated DNA from HIV-infected samples after SECH treatments. We analyzed HIV type 1 (HIV-1) proviruses in these samples by intact proviral DNA assay, near full-length polymerase chain reaction (PCR), and DNA sequencing analyses.
resultsWe show that SECH treatments reduce reservoirs harboring intact but not defective HIV proviruses by intact proviral DNA assay. Nested PCR and DNA sequencing analyses confirm that SECH treatments can delete full-length HIV-1 proviruses in humanized mice in vivo and in patient samples ex vivo.
conclusionsOur data suggest that the SECH method is capable of effectively targeting HIV reservoirs harboring intact HIV proviruses that can restart active viral replication.
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