Evidence map›Paper›PMID 40668915›Full record

ArticleScience advances2025

Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs.

Jonatan Leffler, James F Read, Danny Mok, Michael Serralha, Anthony Bosco, Patrick G Holt, Richard Saffery, Deborah H Strickland

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonatan LefflerWal-yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-5674-8462
James F ReadThe Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0003-2962-6835
Danny MokThe Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-7425-6891
Michael SerralhaThe Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0002-0121-2879
Anthony BoscoAsthma and Airway Disease Research Centre, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-4335-615X
Patrick G HoltWal-yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.
Richard SafferyMurdoch Children's Research Institute, Parkville, Melbourne, VIC, Australia.
Deborah H StricklandWal-yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction of genetic and environmental contributions to immunological traits and their association with atopic disease remain unclear. Flow cytometry and in vitro cytokine responses were used to characterize immune profiles from 93 school-aged twin pairs. Using an established twin pair analytical strategy, the genetic and environmental influences on immunological traits were evaluated, along with their association with atopy. Our findings suggest strong genetic influence on several traits, particularly B cell abundance. In contrast, cytokine responses from in vitro stimulations appeared mainly shaped by environmental exposures. Regarding associations with atopy, greater abundance of both B cells and basophils were observed in atopic individuals as well as increased expression of the immunoglobulin E (IgE) receptor. Genetic influence appeared central to regulating IgE receptor expression on basophils, whereas expression on dendritic cells instead appeared sensitive to environmental exposures. Identifying environmentally regulated immune traits may facilitate the development of targeted therapies to limit the impact of atopic disease in the future.

Indexed as

Hypersensitivity, ImmediateAdolescentBasophilsB-LymphocytesChildCytokinesDendritic CellsFemaleGene-Environment InteractionHumansImmunoglobulin EMaleReceptors, IgETwins, DizygoticCytokinesImmunoglobulin EReceptors, IgE

Identifiers

PMID40668915
PMCPMC12266113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.