ArticleScience advances2025
Childhood skeletal lesions common in prehistory are present in living forager-farmers and predict adult markers of immune function.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- From Optimism to Opportunity: New Perspectives on the Osteological Paradox.American journal of biological anthropology · 2026Review
- Precipitation variability, fertility, and metabolic stress over 5 millennia in the ancient Andes: A bioarchaeological path analysis.Science advances · 2026Article
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Authors and funding
25 authors.
Funding
Abstract
Porous cranial lesions (cribra cranii and cribra orbitalia) are widely used by archaeologists as skeletal markers of poor child health. However, their use has not been validated with systematic data from contemporary populations, where there has been little evidence of these lesions or their health relevance. Using 375 in vivo computed tomography scans from a cohort-representative sample of adults aged 40+ years from the Bolivian Amazon, among food-limited, high-mortality forager-farmers, we identified cribra cranii on 46 (12.3%) and cribra orbitalia on 23 (6%). Cribra orbitalia was associated with several hallmarks of compromised immune function, including fewer B cells, fewer naïve CD4
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