Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
23 authors.
Daqiang ZhaoThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2582-0112
Hehua DaiThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-1595-5737
Camila MacedoThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0003-3624-1896
Steven M SandersThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-5334-4785
Charbel EliasThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-3111-6749
Andrew J FridayThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-3831-457X
Mohamad ZaidanAssistance Publique des Hôpitaux de Paris (AP-HP), INSERM U1184, Université Paris-Saclay, Hôpital de Bicêtre, Le Kremlin-Bicêtre, 94270, France.
Amanda L WilliamsThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Beth D ElinoffThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Martin H OberbarnscheidtThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2040-809X
Jayne DanskaProgram in Genetics and Genome Biology, Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, ON, M5G 0A4, Canada.ORCID 0000-0002-6549-4991
Adriana ZeeviThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-7540-5016
Parmjeet RandhawaThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-7523-3437
Amit D TevarThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0003-0030-6707
Sundaram HariharanThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
David M RothsteinThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-9455-7971
Khodor I Abou-DayaThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8788-2728
Aleksandar SenevComprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-6196-4669
Anat R TamburComprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0320-9825
Diana MetesThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-5500-5074
Olivier ThaunatDepartment of Transplantation, Nephrology, and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon and CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Lyon, 69007, France.ORCID 0000-0002-3648-8963
Fadi G LakkisThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0001-9937-2637
Aravind CherukuriThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0002-8649-2901
Funding
Innate Recognition of Allogeneic Non-SelfR01AI099465 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2012 to 2022
$4.1M
Innate Allorecognition in Clinical Organ TransplantationR01AI172973 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Fadi G. Lakkis · 2023 to 2026
$2.8M
Targeting monocyte allorecognition to achieve allograft acceptanceR01AI181954 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Martin H Oberbarnscheidt · 2025 to 2026
$1.2M
Epigenetic Regulation of Regulatory B Cell Cytokine Expression and Allograft RejectionK08AI166021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aravind Cherukuri · 2022 to 2026
Donor-recipient mismatches in histocompatibility antigens recognized by lymphoid cells have been demonstrated to adversely affect allograft outcomes. In contrast, it remains unclear whether mismatches sensed by innate myeloid cells have a similar effect. We investigated the consequences of mismatch in the polymorphic gene encoding signal regulatory protein α (SIRPα) on kidney allograft pathology and survival in mice and humans. We found that SIRPα variants elicit monocyte activation by binding to CD47 and that eliminating SIRPα mismatch or recipient CD47 expression prevented chronic allograft pathology in mice receiving major histocompatibility complex (MHC)-mismatched renal allografts. Human genomic analysis identified two haplotype categories, A and B, encoding SIRPα variants with distinct CD47 binding interfaces. In kidney transplant recipients (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Donor-recipient mismatch at the · full record | OpenQuestion