Evidence map›Paper›PMID 40668877›Full record

Trial reportEnvironmental science & technology2025

Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial.

Wending Li, Haotian Wu, Jeff Goldsmith, Ronald A Glabonjat, Vesna Ilievski, Olgica Balac, Vesna Slavkovich, Brismar Pinto-Pacheco, Xiangping Lin, Faruque Parvez and 13 more

Abstract readClinical Trial, Phase IVRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Wending LiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0001-5405-8708
Haotian WuDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0002-6271-0249
Jeff GoldsmithDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Ronald A GlabonjatDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Vesna IlievskiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Olgica BalacDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Vesna SlavkovichDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Brismar Pinto-PachecoDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Xiangping LinDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Faruque ParvezDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Gabriela L JacksonDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Abu B SiddiqueColumbia University Arsenic Project in Bangladesh, Dhaka 1450, Bangladesh.
Mohammad Nasir UddinColumbia University Arsenic Project in Bangladesh, Dhaka 1450, Bangladesh.ORCID 0000-0003-0223-9763
Tariqul IslamColumbia University Arsenic Project in Bangladesh, Dhaka 1450, Bangladesh.
Irene Martinez-MorataDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Ana Navas-AcienDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Megan M NiedzwieckiDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.ORCID 0000-0001-6647-141X
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Brandon L PierceDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois 60637, United States.
Joseph H GrazianoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Teodoro BottiglieriCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, Texas 75226, United States.
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States.
Mary V GambleDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Research Experience and Training Coordination CoreP42ES033719 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARCIA O'LEARY · 2022 to 2026
$11.9M
Arsenic and the Human Genome: susceptibility and response to exposure Supplement 4R35ES028379 · NIEHS · UNIVERSITY OF CHICAGO · PI PIERCE, BRANDON LEE · 2017 to 2024
$5.6M
Metabolomic and nutrigenetic effects of folic acid supplementation and unmetabolized folic acidR01DK123285 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2020 to 2023
$2.6M
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood ArenicR01CA133595 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2009 to 2013
$2.3M
Interdisciplinary approaches for understanding the metabolic effects of arsenic and manganeseR01ES030945 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2020 to 2022
$1.9M
NCI NIH HHS R01 CA133595NIDDK NIH HHS R01 DK123285NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES027792NIEHS NIH HHS P42 ES033719NIEHS NIH HHS R01 ES030945NIEHS NIH HHS R35 ES028379
6 · The paper itself

Abstract

Arsenic exposure remains a leading public health concern. Folic acid (FA) supplementation enhances one-carbon metabolism (OCM), thus promoting arsenic methylation and facilitating urinary arsenic elimination. Here, we investigate the metabolic profiles linked to arsenic exposure and metabolism based on a FA clinical trial. Arsenic exposure was assessed by the concentrations of blood arsenic (bAs) species: arsenite [InAs

Indexed as

ArsenicCreatineFolic AcidAdultFemaleHumansMaleArsenicCreatineFolic Acidarsenicfolic acidmetabolomicsone-carbon metabolismrandomized controlled trial

Identifiers

PMID40668877
PMCPMC12312088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.