Evidence map›Paper›PMID 40668813›Full record

ArticlePLOS global public health2025

Perceived shifts in routine vaccine confidence during the COVID-19 pandemic in Kinshasa Province, DRC: A mixed-methods approach.

Alix Boisson-Walsh, Patrick Ngimbi, Camille E Morgan, Angela M Stover, Nana Mbonze, Sarah Ntambua, Jolie Matondo, Marcel Yotebieng, Melchior M Kashamuka, Linda James and 3 more

Erratum issuedAbstract read
In one paragraph

Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Alix Boisson-WalshDivision of Infectious Diseases, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-6180-1931
Patrick NgimbiFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Camille E MorganDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, North Carolina, United States of America.ORCID https://orcid.org/0000-0003-1315-0908
Angela M StoverDepartment of Health Policy and Management, Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina, United States of America.ORCID https://orcid.org/0000-0003-0983-686X
Nana MbonzeFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Sarah NtambuaFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Jolie MatondoFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Marcel YotebiengDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Melchior M KashamukaL'École de Santé Publique, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
Linda JamesFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Jonathan B ParrDivision of Infectious Diseases, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Samuel MampunzaFaculté de Médecine, Université Protestante au Congo, Kinshasa, Democratic Republic of the Congo.
Peyton ThompsonDivision of Infectious Diseases, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-9679-9763

Funding

"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/MalignanciesU54CA254568 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI YOTEBIENG, MARCEL · 2020 to 2024
$5.1M
HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic studyR01HD105526 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KWIEK, JESSE J, YOTEBIENG, MARCEL · 2021 to 2025
$3.6M
Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR CongoR01HD087993 · NICHD · OHIO STATE UNIVERSITY · PI BABAKAZO, PELAGIE DIAMBALULA, YOTEBIENG, MARCEL · 2016 to 2020
$3.1M
Lung Cancer Screening: Cumulative Risk and Multilevel Impact of False Positive FindingsR01CA285976 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Louise Henderson, Maria Patricia Rivera · 2024 to 2026
$1.9M
Characterizing Hepatitis B Transmission in Congolese ChildrenK08AI148607 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THOMPSON, PEYTON J · 2020 to 2024
$1.0M
Spatial and molecular epidemiology of hepatitis B transmission in the Democratic Republic of the CongoF30AI169752 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Camille Morgan · 2022 to 2026
$200k
FIC NIH HHS D43 TW009340NCI NIH HHS R01 CA285976NCI NIH HHS U54 CA254568NIAID NIH HHS F30 AI169752NIAID NIH HHS K08 AI148607NIAID NIH HHS U01 AI096299NICHD NIH HHS R01 HD087993NICHD NIH HHS R01 HD105526
6 · The paper itself

Abstract

The COVID-19 pandemic negatively impacted routine immunizations worldwide, decreasing confidence in vaccination programs. We used mixed methods to examine changes in vaccine confidence from before to during the pandemic in HBV-negative adults in Kinshasa who were exposed to HBV in the household, and eligible for HBV vaccination. We measured changes in routine HBV vaccine confidence with a previously validated Shift in Vaccine Confidence (SVC) self-report measure that was verbally administered in Lingala (local language). We compared vaccination confidence before versus during the pandemic using Chi-square tests. We also interviewed participants and coded open-ended responses to the SVC scale to explore context-specific perceptions. From April 2022 to February 2023, we administered the SVC tool to a purposive sample of 41 participants: 7 vaccinees, 23 willing to receive HBV vaccine, and 11 refusers. Participants had a median age of 32 years, were predominantly affiliated with Revivalist churches, and most reported unemployment and no education beyond secondary school. We observed statistically significant declines across all five vaccine confidence domains when comparing responses before and during the pandemic (p < 0.01): vaccines prevent diseases (85.4%-68.3%), are safe (80.5%-46.3%), important for a child's health (92.7%-87.8%) and one's own health (87.8%-68.3%), and new vaccines carry no more risk than routine vaccines (78.1%-63.5%). Qualitative analysis identified four themes impacting uptake decisions: vaccine confidence, knowledge, risks, and external influences. Rising uncertainty about efficacy, safety, and distrust in the COVID-19 vaccine undermined vaccine confidence among our participants. Factors such as distrust in manufacturers and government, fear of side effects, perceived low illness risk, and inconvenient healthcare access contributed to low vaccine uptake. These insights underscore the pandemic's impact on routine immunization and emphasize the need for consideration in future vaccination campaigns.

Identifiers

PMID40668813
PMCPMC12266390

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.