ArticlePloS one2025
Global, regional, and national burden of early-onset OA attributable to high BMI: 1990-2021 estimates and 2036 projections from the global burden of disease study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Burdens of Idiopathic Developmental Intellectual Disability Attributable to Lead Exposure from 1990 to 2023 and a Projection to 2050 in the USA: Findings from the Global Burden of Disease Study 2023.Healthcare (Basel, Switzerland) · 2026Article
- Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh BMI is a critical risk factor for early-onset OA (diagnosed before age 55). This study aimed to analyze global trends in the age-standardized disability-adjusted life years rates (ASDR) attributable to high BMI from 1990 to 2021.
methodsData from the Global Burden of Disease 2021 (GBD 2021) study were analyzed to assess early-onset OA attributable to high BMI across 204 countries, 21 GBD regions, and 5 Socio-Demographic Index (SDI) tiers. Temporal trends in ASDR were quantified using the estimated annual percentage change (EAPC) and Joinpoint regression. Age-period-cohort models and decomposition analysis identified drivers of burden, while inequality was assessed using the Slope Index of Inequality (SII) and Concentration Index (CI). ARIMA models projected trends to 2036.
resultsThe disease burden of early-onset OA attributable to high BMI increased significantly between 1990 and 2021. The DALYs for early-onset knee and hip OA rose by 203.01% and 170.12%, respectively, with average annual percentage changes (AAPC) of 1.39% and 1.40%. The age-period-cohort analysis indicated that DALYs risk increased with age and period, and later birth cohorts experienced a higher burden of early-onset OA attributable to high BMI. Decomposition analysis revealed that population growth was the primary driver of the rising disease burden. There were significant absolute and relative inequalities in the burden of early-onset OA attributable to high BMI, as measured by the SDI. Countries with higher SDI bore a greater burden. The SII demonstrated that the ASDR gap between countries with the highest and lowest SDI widened steadily from 1990 to 2021. Predictive analysis suggested that the burden of early-onset OA attributable to high BMI will continue to increase over the next 15 years.
conclusionFrom 1990 to 2021, the global burden of early-onset OA attributable to high BMI showed a consistent upward trend, with significant inequalities across countries. The disease burden is projected to grow further in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.