Evidence map›Paper›PMID 40668710›Full record

ArticleIEEE transactions on bio-medical engineering2026

Bayesian Temporal Prediction: A Robust Algorithm for Real-Time EEG Phase-Dependent Brain Stimulation.

Sina Shirinpour, Ivan Alekseichuk, Malte R Guth, Zachary Haigh, Miles Wischnewski, Alexander Opitz

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Personalized, EEG-controlled intermittent theta burst stimulation.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sina Shirinpour
Ivan Alekseichuk
Malte R Guth
Zachary Haigh
Miles Wischnewski
Alexander Opitz

Funding

Validation of Closed-Loop Prefrontal Transcranial Magnetic Stimulation in a Non-Human Primate ModelR01MH136053 · NIMH · UNIVERSITY OF MINNESOTA · PI Arnaud Y Falchier, Alexander Opitz · 2024 to 2026
$2.4M
Personalized Closed-loop Theta Burst Stimulation for Treatment of DepressionR00MH128454 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ivan Alekseichuk · 2024 to 2026
$731k
Personalized Closed-loop Theta Burst Stimulation for Treatment of DepressionK99MH128454 · NIMH · UNIVERSITY OF MINNESOTA · PI ALEKSEICHUK, IVAN · 2022 to 2023
$212k
NIMH NIH HHS K99 MH128454NIMH NIH HHS R00 MH128454NIMH NIH HHS R01 MH136053
6 · The paper itself

Abstract

objectiveReal-time estimation of brain state is essential for efficient brain stimulation. Specifically, the electroencephalography (EEG) oscillation phase arose as a promising biomarker for instantaneous brain excitability, making it ideal for state-dependent brain stimulation. Current methods for real-time EEG phase extraction lose accuracy in the presence of non-stationary noise, motivating the development of a more robust and accurate algorithm. Here, we propose and validate Bayesian Temporal Prediction (BTP) as an effective method for EEG phase detection in real-time.

methodsBTP utilizes a short pre-session EEG recording and learning of the personalized prediction parameters, enabling subsequent high-precision real-time phase detection. We experimentally validate BTP in humans and compare its performance to a strong benchmark algorithm.

resultsBTP demonstrates accurate EEG oscillation phase detection across a broad range of conditions and target oscillations, facilitating personalized brain stimulation.

conclusionThis study introduces BTP as a robust, computationally efficient, and accurate method for EEG state-dependent stimulation. SIGNIFICANCE: The widespread adoption of BTP in research and clinical settings has the potential to enhance treatment efficacy and minimize inter- and intra-individual variability in brain stimulation interventions.

Indexed as

AlgorithmsBrainElectroencephalographySignal Processing, Computer-AssistedAdultBayes TheoremFemaleHumansMaleYoung Adult

Identifiers

PMID40668710
PMCPMC12395933

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.