Evidence map›Paper›PMID 40668645›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Macro- and microinjury define the heart failure progression after permanent coronary ligation or ischemia-reperfusion in young healthy mice.

Gabriel Araujo Grilo, Jeremias Munoz, Dae Hyun Lee, Shahriare Hossain, Yonggang Ma, Vasundhara Kain, Merry L Lindsey, Ganesh V Halade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel Araujo GriloDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.
Jeremias MunozDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0009-0005-6034-378X
Dae Hyun LeeDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0000-0001-8141-0404
Shahriare HossainDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-4303-705X
Yonggang MaMorsani College of Medicine, Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-1711-0639
Vasundhara KainDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0000-0001-8571-8553
Merry L LindseySchool of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States.ORCID 0000-0002-4090-0391
Ganesh V HaladeDivision of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, Heart Institute, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-5351-9354

Funding

T Lymphopenia in Ischemic Heart FailureR01HL164446 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Yonggang Ma · 2022 to 2026
$2.0M
Resolution of Inflammation in Heart Failure Post-Myocardial InfarctionR01HL132989 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2016 to 2020
$1.8M
Lipoxygenase Signaling in Heart Failure PathologyR01HL144788 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2019 to 2022
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL132989HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL144788HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL164446NHLBI NIH HHS R01 HL132989NHLBI NIH HHS R01 HL144788NHLBI NIH HHS R01 HL164446
6 · The paper itself

Abstract

Heart failure (HF) is a major outcome in cardiovascular disease resulting from myocardial infarction (MI). Preclinical studies use MI-induced HF rodent models with either permanent coronary occlusion (PO) or transient ligation to induce ischemia-reperfusion (I/R). Comparisons of inflammation-resolution signaling in these models are understudied. Two-month-old C57BL/6J mice underwent either permanent ligation of the left anterior descending (LAD) coronary artery (PO,

Indexed as

Coronary OcclusionHeart FailureMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumAnimalsDisease Models, AnimalDisease ProgressionEchocardiographyInflammation MediatorsLigationMaleMiceMice, Inbred C57BLVentricular Function, LeftVentricular RemodelingInflammation Mediatorscardiac injuryfunctional recoveryheart failureinfarct areainflammation-resolution signaling

Identifiers

PMID40668645
PMCPMC12771688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.