ReviewAmerican journal of physiology. Cell physiology2025
The evolution of chemical biology into translational physiology and precision medicine.
Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Pharmaceutical research has undergone significant transformation over time, particularly in the development of potent compounds that target specific physiological mechanisms. The need to demonstrate clinical benefit posed challenges. These challenges led to the rise of translational physiology and precision medicine aided by the development of the chemical biology platform. The chemical biology platform is an organizational approach to optimize drug target identification and validation and improve safety and efficacy of biopharmaceuticals. The platform achieves this goal through emphasis on understanding the underlying biological processes and leveraging knowledge gained from the action of similar molecules on these biological processes. The platform connects a series of strategic steps to determine whether a newly developed compound could translate into clinical benefit using translational physiology. Translational physiology examines biological functions across multiple levels, from molecular interactions to population-wide effects, and has been deeply influenced by the advancement of the chemical biology platform. Unlike traditional trial-and-error methods, by leveraging systems biology techniques, such as proteomics, metabolomics, and transcriptomics, chemical biology prioritizes targeted selection to enhance drug discovery. This historical review explores the evolution of the chemical biology platform and its role in precision medicine, highlighting its continued influence in both academic research and pharmaceutical innovation. By fostering a mechanism-based approach to clinical advancement, chemical biology remains a critical component in modern drug development. In addition, understanding the history and integrative nature of this platform is essential for training the next generation of researchers in the design of experimental studies that effectively incorporate translational physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.