Evidence map›Paper›PMID 40668608›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2025

Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use.

Zhiying Shen, Wai Hon Lee, Jacob A Eastman, Michaela R Frenzel, Alex I Wiesman, Tony W Wilson, Elizabeth A Walker, Ryan W McCreery, Elizabeth Heinrichs-Graham

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiying ShenCognitive and Sensory Imaging Laboratory, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.ORCID 0009-0006-3363-4829
Wai Hon LeeCognitive and Sensory Imaging Laboratory, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.
Jacob A EastmanCenter for Pediatric Brain Health, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.
Michaela R FrenzelDynamic Imaging of Cognition and Neuromodulation Laboratory, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.
Alex I WiesmanDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Dr. E. K9625, Burnaby, BC V5A 1S6, Canada.
Tony W WilsonCenter for Pediatric Brain Health, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.
Elizabeth A WalkerWendell Johnson Speech and Hearing Center, Department of Communication Sciences and Disorders, University of Iowa, 250 Hawkins Dr., Iowa City, IA 52242, United States.
Ryan W McCreeryCenter for Pediatric Brain Health, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.
Elizabeth Heinrichs-GrahamCognitive and Sensory Imaging Laboratory, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln., Boys Town, NE 68010, United States.ORCID 0000-0002-7914-5258

Funding

The Impact of Mild Hearing Loss on Auditory Perception in Complex EnvironmentsP20GM109023 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI MCGREGOR, KARLA · 2014 to 2023
$23.4M
Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive ControlP20GM144641 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI Giorgia Picci · 2022 to 2026
$15.1M
COMPLEX LISTENING SKILLS IN SCHOOL-AGE HARD OF HEARING CHILDRENR01DC013591 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI MCCREERY, RYAN W. · 2014 to 2023
$4.8M
Spatiotemporal Dynamics of Language Processing in School-Age Children with Mild-to-Severe Hearing LossR21DC020270 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI HEINRICHS-GRAHAM, ELIZABETH · 2023 to 2025
$608k
NIDCD NIH HHS R01 DC013591NIDCD NIH HHS R21 DC020270NIGMS NIH HHS P20 GM109023NIGMS NIH HHS P20 GM144641NIH HHS P20-GM144641NIH HHS R01-DC013591NIH HHS R21-DC020270Tier-2 Canada Research Chair program CRC-2023-00300
6 · The paper itself

Abstract

Children who are hard-of-hearing (CHH) show greater variability in language and academic outcomes than children with normal hearing (CNH) throughout development, despite early detection and intervention. Nonetheless, our understanding of the neural mechanisms underlying sensory and cognitive processing in CHH remains incomplete. The 40-Hz cortical auditory steady-state response (ASSR) has been widely used as a marker of auditory system integrity and shown to relate to cognition. Thus, the current study sought to determine the impact of mild-to-severe hearing loss on cortical ASSR dynamics. Thirty-seven participants ages 7-15 years old heard a broadband click train stimulus presented at 40 Hz binaurally during magnetoencephalography (MEG). Peak sources in the bilateral primary auditory cortices were identified, and the power envelope of the 40 Hz ASSR was extracted as a function of time and submitted to linear mixed modeling. We found a significant three-way interaction, suggesting that CHH exhibit altered ASSR dynamics between hemispheres compared to CNH. Moreover, hearing aid use was significantly correlated with left hemisphere ASSR power in CHH. These data underscore the importance of consistent auditory access in CHH and provide preliminary evidence that neuroimaging may hold promise in determining the mechanisms underlying behavioral variability in this population.

Indexed as

Auditory CortexAuditory PerceptionEvoked Potentials, AuditoryHearing AidsHearing LossAcoustic StimulationAdolescentChildFemaleHumansMagnetoencephalographyMaleauditory experiencemagnetoencephalographyneurophysiologyoscillationssensory processing

Identifiers

PMID40668608
PMCPMC12265889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.