ArticleMolecular biology of the cell2025
GAS2L1 facilitates Golgi-derived microtubule growth and Golgi organization.
Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Golgi complex serves as a major noncentrosomal microtubule-organizing center in animal cells, with Golgi-derived microtubules playing a crucial role in Golgi assembly, structural organization, cell migration, and various Golgi-related cellular functions. In this study, we identify GAS2L1 as a key regulator of Golgi-based microtubule growth and Golgi reassembly. Loss of GAS2L1 leads to significant defects in Golgi morphology and impairs nocodazole washout-induced Golgi reassembly. Notably, microtubule regrowth from the Golgi after nocodazole treatment is markedly inhibited in GAS2L1-knockout cells. Furthermore, we demonstrate that GAS2L1 interacts with CLASP1/2, known regulators of Golgi-derived microtubules, suggesting that GAS2L1 functions in concert with CLASP1/2 to regulate Golgi-associated microtubule dynamics. These findings provide new insights into the molecular mechanisms governing Golgi-derived microtubules, expanding our understanding beyond the established roles of CLASP1/2.
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