Evidence map›Paper›PMID 40668524›Full record

ReviewIrish journal of medical science2025

BDNF-TrkB signalling: a neurotrophic pathway to cardiovascular protection.

Amita Joshi Rana, Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Sreeshma Ravindran Kammarambath, Rajesh Raju, Inamul Hasan Madar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Effects ofPreventive nutrition and food science · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amita Joshi RanaCollege of Pharmacy, Graphic Era Hill University, Bhimtal, Uttarakhand, 263136, India.ORCID http://orcid.org/0000-0003-1907-4459
Md Sadique HussainUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Dehradun, Uttarakhand, 248007, India.ORCID http://orcid.org/0000-0002-3554-1750
Vikas JakhmolaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Dehradun, Uttarakhand, 248007, India.ORCID http://orcid.org/0000-0002-8108-006X
Ayesha SultanaDepartment of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.ORCID http://orcid.org/0000-0003-3773-6604
Sreeshma Ravindran KammarambathCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, 575018, Karnataka, India.ORCID http://orcid.org/0009-0008-9971-5116
Rajesh RajuCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, 575018, Karnataka, India.ORCID https://orcid.org/0000-0003-2319-121X
Inamul Hasan MadarCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, 575018, Karnataka, India. oncoinam@gmail.com.ORCID http://orcid.org/0000-0002-6913-1776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (TrkB) signaling axis has emerged as a promising frontier in cardiovascular research, particularly in the context of myocardial ischemia/reperfusion (I/R) injury. Originally recognized for its neuroprotective functions, BDNF is now gaining recognition for its cardioprotective properties, including anti-apoptotic effects, improved cardiomyocyte survival, and enhanced contractile function. Acting predominantly through TrkB, BDNF attenuates ischemia-induced apoptosis by downregulating caspase-3 and cleaved caspase-9, while simultaneously promoting cardiomyocyte differentiation and proliferation. Intriguingly, under hypoxic conditions, a shift from p75NTR to TrkB receptor activity amplifies these protective effects. Moreover, BDNF modulates intracellular calcium handling by activating Ca

Indexed as

Brain-Derived Neurotrophic FactorCardiotonic AgentsReceptor, trkBCalcium-Calmodulin-Dependent Protein Kinase Type 2Cardiovascular SystemHumansMyocardial IschemiaMyocardial ReperfusionMyocardial Reperfusion InjuryProtective AgentsSignal TransductionBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2Cardiotonic AgentsProtective AgentsReceptor, trkBBrain-derived neurotrophic factorCalcium signalingCardiac remodelingCardiomyocytesCardiovascular diseasesMyocardial ischemia/reperfusion injuryTrkB/BDNF signaling pathwayTropomyosin receptor kinase B

Identifiers

PMID40668524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.