Evidence map›Paper›PMID 40668487›Full record

ReviewEndocrine pathology2025

Roadmap to Challenges in Limited Cellularity Specimens from Pancreatic Neuroendocrine Neoplasms: Diagnostic Tools for the Most Appropriate Management of Limited Material.

Stefano La Rosa, Roberta Maragliano, Deborah Marchiori

Abstract readReview
In one paragraph

Review in Endocrine pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefano La RosaUnit of Pathology, Department of Medicine and Technological Innovation, University of Insubria, Viale Borri 57, 21100, Varese, Italy. stefano.larosa@uninsubria.it.
Roberta MaraglianoUnit of Pathology, Department of Oncology, ASST Sette Laghi, Varese, Italy.
Deborah MarchioriUnit of Pathology, Department of Oncology, ASST Sette Laghi, Varese, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fine needle aspiration (FNA) and fine needle biopsy (FNB) procedures are increasingly employed in the diagnostic work-up of pancreatic masses. These procedures represent a challenge for pathologists who have to adapt to handling specimens of limited cellularity. In several cases, FNA and FNB specimens are the only available material, as many pancreatic neoplasms are surgically unresectable at the time of the initial diagnosis. In the present review paper, the diagnosis of pancreatic neuroendocrine neoplasms in limited cellularity specimens is presented using a morphology-based approach. The aim is to provide a practical guide for pathologists to select the most appropriate ancillary techniques to be used for the diagnostic work-up, while conserving precious material. The integration of morphology, immunohistochemistry, and molecular biology will be discussed to provide the reader with practical tools to solve the main differential diagnostic problems encountered in routine practice when working with cytological samples or small biopsies.

Indexed as

Neuroendocrine TumorsPancreatic NeoplasmsBiopsy, Fine-NeedleHumansImmunohistochemistrySpecimen HandlingFine needle aspirationFine needle biopsyNeuroendocrine neoplasms

Identifiers

PMID40668487
PMCPMC12681476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.