Evidence map›Paper›PMID 40668467›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Intracranial vessel wall lesions on MRI: anatomical and pathological issues.

Marialuisa Zedde, Massimo Del Sette, Rocco Quatrale, Francesco Causin, Rosario Pascarella

Abstract readReview
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In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. When thrombus meets intracranial dissection: a tricky decision for intravenous thrombolysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, Reggio Emilia, 42122, Italy. zedde.marialuisa@ausl.re.it.ORCID http://orcid.org/0000-0001-7530-818X
Massimo Del SetteNeurology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy.
Rocco QuatraleDipartimento Di Scienze Neurologiche, UOC di Neurologia-Ospedale dell'Angelo-ULSS 3 Serenissima, Venezia-Mestre, 30174, Italy.
Francesco CausinNeuroradiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Rosario PascarellaNeuroradiology Unit, Ospedale Santa Maria della Misericordia, AULSS 5 Polesana, Rovigo, 45100, Italy.ORCID http://orcid.org/0000-0002-0512-9298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVessel Wall Imaging (VWI) is a Magnetic Resonance (MR) technique whose employment is more and more frequent for investigating intracranial arterial diseases. This is mainly due to its potential to see beyond the arterial luminal stenosis giving information on the arterial walls. This promising role could help to distinguish among several causes of intracranial arteriopathies (atherosclerosis, vasculitis, Moyamoya, etc.) and to predict the instability of plaques and aneurysms.

aimsIn this review, the main technical issues and potential source of misinterpretation of VWI were analyzed and the data provided by the literature on pathological validation of these findings were critically proposed, in order to better define the limitations and the future potential of this method.

findingsOnly in isolated cases the main findings of VWI were validated against histopathology and in several diseases, there is not a pathological validation of the interpretation of abnormal findings of VWI technique.

conclusionsThe lack of a pathological substrate underlying wall contrast enhancement and wall thickening (two of the most characterizing aspects of this technique) makes difficult to rely only on this technique for drawing a conclusive diagnosis.

Indexed as

Intracranial Arterial DiseasesMagnetic Resonance ImagingHumansAneurysmAther-osclerosisICADIntracranial arteriopathiesIntracranial stenosisMRIPACNSPlaqueVasculitisVessel wall imagingVWIWall enhancement

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.