ArticleRice (New York, N.Y.)2025
The Histidine-25-Arginine Mutation in the Rice MACPF Protein OsCAD1 Induces Cell Death and Activates Defense Responses in the Lesion Mimic Mutant spl17.
Article in Rice (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Red Light Triggers Lesion Formation in thePlants (Basel, Switzerland) · 2026Article
- Transcriptomic and metabolomic analyses revealFrontiers in plant science · 2026Article
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8 authors.
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Abstract
Plants defend themselves against pathogens through pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), with the latter often inducing a hypersensitive response (HR) characterized by localized programmed cell death (PCD). Lesion mimic mutants (LMMs), which spontaneously form HR-like lesions in the absence of pathogen infection, have served as valuable genetic resources for dissecting the molecular mechanisms underlying cell death and immune signaling in plants. In this study, we characterize the rice lesion mimic mutant spl17, derived from the IR64 cultivar, and identify the mutation responsible for its phenotype. We demonstrate that the spl17 mutation leads to the accumulation of reactive oxygen species (ROS), induces light-dependent cell death and lesion formation, elevates levels of salicylic acid (SA) and jasmonic acid (JA), activates defense-related genes, and confers enhanced resistance to Xanthomonas oryzae pv. oryzae. Using map-based cloning, we identified a single Histidine-25-Arginine substitution (OsCAD1
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