Evidence map›Paper›PMID 40668308›Full record

ArticleAging clinical and experimental research2025

Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.

Jun Lu, Frank Mastaglia, Andrew Chi Pang Tai, Max K Bulsara, William G Blakeney, Charles A Inderjeeth, Minghao Zheng, Jun Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun LuPerron Institute for Neurological and Translational Science, University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia.
Frank MastagliaPerron Institute for Neurological and Translational Science, University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia.
Andrew Chi Pang TaiPerron Institute for Neurological and Translational Science, University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia.ORCID http://orcid.org/0000-0002-9120-7562
Max K BulsaraInstitute for Health Research, University of Notre Dame Australia, 23 High St, Fremantle, WA, 6160, Australia.
William G BlakeneyDepartment of Orthopaedic Surgery, Royal Perth Hospital, Wellington Street, Perth, WA, 6000, Australia.
Charles A InderjeethSir Charles Gairdner Osborne Park Health Care Group, Hospital Ave, Gerontorheumatology, Nedlands, WA, 6009, Australia.
Minghao ZhengPerron Institute for Neurological and Translational Science, University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia. minghao.zheng@uwa.edu.au.ORCID http://orcid.org/0000-0003-1185-4768
Jun YuanPerron Institute for Neurological and Translational Science, University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia. jun.yuan@perron.uwa.edu.au.ORCID http://orcid.org/0000-0001-6542-4654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporosis and dementia are two common disorders mainly affecting ageing population, and heel estimated bone mineral density (eBMD) measured by quantitative ultrasound (QUS) has been demonstrated to be a reliable and non-invasive method for assessing skeletal health. The aim of this study is to determine the association between eBMD and incident dementia in older adults.

methodsThis retrospective cohort study employs UK Biobank data of 131,030 adults aged ≥ 60 years without dementia at baseline. Cox proportional-hazards models were used to investigate the association between eBMD and incident dementia, with the C-index evaluating the discriminative potential of eBMD.

resultsAmong participants (52.1% women, median [IQR] age was 64 [62-66] years), there were 4,572 cases (3.5%) of incident dementia. Minimal model showed that participants with low eBMD (< 0.467 g/cm

conclusionLower heel eBMD is independently associated with increased dementia risk among older adults.

Indexed as

AgingBone DensityDementiaHeelAgedBiological Specimen BanksFemaleHumansIncidenceMaleMiddle AgedOsteoporosisProportional Hazards ModelsRetrospective StudiesRisk FactorsUK BiobankCohort studiesDementiaEstimated bone mineral densityOsteoporosisUK Biobank

Identifiers

PMID40668308
PMCPMC12267336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.