Evidence map›Paper›PMID 40668268›Full record

ReviewDiscover nano2025

Biofilms and oral health: nanotechnology for biofilm control.

Deenadayalan Karaiyagowder Govindarajan, Maline Mohanarangam, Lohita Kadirvelu, Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Anand Ravichandran, Saravanan Periasamy, Kumaravel Kandaswamy

Abstract readReview
In one paragraph

Review in Discover nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Article
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  8. Review
  9. Article
  10. Cannabidiol (CBD) InhibitsInternational journal of dentistry · 2026
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deenadayalan Karaiyagowder GovindarajanDepartment of Biotechnology, Research Center for Excellence in Microscopy, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, 641 049, India.
Maline MohanarangamDepartment of Biotechnology, Center of Excellence in Biofilms, Rajalakshmi Engineering College, Autonomous, Chennai, Tamil Nadu, 602 105, India.
Lohita KadirveluDepartment of Biotechnology, Research Center for Excellence in Microscopy, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, 641 049, India.
Sowmiya Sri SivaramalingamDepartment of Biotechnology, Research Center for Excellence in Microscopy, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, 641 049, India.
Deepsikha JothivelDepartment of Biotechnology, Research Center for Excellence in Microscopy, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, 641 049, India.
Anand RavichandranDepartment of Biotechnology, Center of Excellence in Biofilms, Rajalakshmi Engineering College, Autonomous, Chennai, Tamil Nadu, 602 105, India.
Saravanan PeriasamyDepartment of Biotechnology, Center of Excellence in Biofilms, Rajalakshmi Engineering College, Autonomous, Chennai, Tamil Nadu, 602 105, India.
Kumaravel KandaswamyDepartment of Biotechnology, Research Center for Excellence in Microscopy, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, 641 049, India. kumaravel.k.bt@kct.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental biofilms are complex microbial communities enclosed by a self-produced extracellular matrix, leading to dental caries, periodontitis, and other oral diseases. These biofilms are often resistant to conventional antibiotics and result in persistent infections that negatively impact oral health. Recent advances in nanotechnology have demonstrated nanoparticles as a promising therapeutic alternative for controlling dental biofilms. In addition, such nanoparticles possess unique physicochemical properties such as high surface area-to-volume ratio, enhanced reactivity, and ability to penetrate biofilm structures. Therefore, this review explores the potential of various nanoparticles, such as silver, zinc oxide, and titanium dioxide, in disrupting biofilm formation and removal of pathogenic oral biofilm forming bacteria. Additionally, this review critically examines various strategies for surface functionalization of nanoparticles to enhance their antimicrobial efficacy and biofilm-targeting capabilities. Furthermore, the article also presents various applications of dental materials coated with nanoparticles in preventing biofilm adhesion and growth. In essence, this review article will provide collective information on various approaches in using nanoparticles to reduce the risk of recurrent oral infections and enhance overall dental health.

Indexed as

Antimicrobial coatingBiofilm disruptionDental biofilmNanoparticlesOral health

Identifiers

PMID40668268
PMCPMC12267812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.