Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
39 authors.
Alessandro ManconLaboratory of Clinical Microbiology, Virology and Bioemergencies, Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan, Italy.ORCID 0000-0002-1490-636X
Laura PellegrinelliDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID 0000-0003-2344-6032
Greta RomanoMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-9076-8501
Elisa VianDepartment of Specialist and Laboratory Medicine, Unitá Operativa Complessa Microbiology Treviso Hospital, Azienda Unitá Locale Socio Sanitaria 2 La Marca, Treviso, Italy.ORCID 0000-0002-4315-6342
Valeria BiscaroDepartment of Specialist and Laboratory Medicine, Unitá Operativa Complessa Microbiology Treviso Hospital, Azienda Unitá Locale Socio Sanitaria 2 La Marca, Treviso, Italy.
Giulia PiccirilliMicrobiology Unit, Istituto Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID 0000-0002-2596-2367
Tiziana LazzarottoMicrobiology Unit, Istituto Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID 0000-0003-3093-363X
Sara Uceda RenteriaMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-2027-8478
Annapaola CallegaroMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Elisabetta PaganiSüdtiroler Sanitätsbetrieb Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (Azienda Sanitaria Dell' Alto Adige), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy.ORCID 0000-0002-4008-6756
Elisa MasiSüdtiroler Sanitätsbetrieb Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (Azienda Sanitaria Dell' Alto Adige), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy.
Guglielmo FerrariMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.ORCID 0000-0003-1478-6094
Cristina GalliDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID 0000-0002-0450-4156
Francesca CentroneHygiene Unit, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy.ORCID 0000-0003-3018-5408
Maria ChironnaHygiene Unit, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy.ORCID 0000-0002-1043-1256
Claudia TiberioUnitá Operativa Complessa Microbiology and Virology, Cotugno Hospital Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Erasmo FalcoUnitá Operativa Complessa Microbiology and Virology, Cotugno Hospital Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Valeria MicheliLaboratory of Clinical Microbiology, Virology and Bioemergencies, Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan, Italy.ORCID 0000-0001-5629-3875
Federica NovazziDepartment of Medicine and Innovation Technology (DIMIT), University of Insubria, Varese, Italy.ORCID 0000-0002-2741-8840
Nicasio ManciniDepartment of Medicine and Innovation Technology (DIMIT), University of Insubria, Varese, Italy.ORCID 0000-0003-0637-0910
Tiziano Giacomo AlliceLaboratory of Microbiology and Virology, Amedeo di Savoia Hospital, Azienda Sanitaria Locale Città di Torino, Torino, Italy.ORCID 0000-0002-9842-8392
Francesco CeruttiLaboratory of Microbiology and Virology, Amedeo di Savoia Hospital, Azienda Sanitaria Locale Città di Torino, Torino, Italy.ORCID 0000-0003-0480-8296
Elena PomariDepartment of Infectious-Tropical Diseases and Microbiology, Istituto Ricovero e Cura a Carattere Scientifico Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.ORCID 0000-0002-5182-0231
Concetta CastillettiDepartment of Infectious-Tropical Diseases and Microbiology, Istituto Ricovero e Cura a Carattere Scientifico Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.ORCID 0000-0001-9819-236X
Eleonora LalleLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani Istituto Ricovero e Cura a Carattere Scientifico, Rome, Italy.ORCID 0000-0002-7063-9905
Fabrizio MaggiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani Istituto Ricovero e Cura a Carattere Scientifico, Rome, Italy.ORCID 0000-0001-7489-5271
Matteo FracellaLaboratory of Microbiology and Virology, Department of Molecular Medicine, University of Rome La Sapienza, Rome, Italy.ORCID 0000-0002-2885-2382
Paolo RavaniniLaboratory of Microbiology and Virology, Maggiore della Carità Hospital, Novara, Italy.
Giulia FaolottoLaboratory of Microbiology and Virology, Maggiore della Carità Hospital, Novara, Italy.ORCID 0000-0003-4558-3230
Roberta SchiavoMicrobiology and Virology Unit, Hospital Guglielmo da Saliceto Hospital, Piacenza, Italy.
Giuliana Lo CascioMicrobiology and Virology Unit, Hospital Guglielmo da Saliceto Hospital, Piacenza, Italy.ORCID 0000-0003-3971-2008
Carla AcciarriDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
Stefano MenzoDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.ORCID 0000-0002-4425-3750
Fausto BaldantiMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-3358-8969
Guido AntonelliLaboratory of Microbiology and Virology, Department of Molecular Medicine, University of Rome La Sapienza, Rome, Italy.ORCID 0000-0002-2533-2939
Alessandra PierangeliLaboratory of Microbiology and Virology, Department of Molecular Medicine, University of Rome La Sapienza, Rome, Italy.ORCID 0000-0003-0633-360X
Elena ParianiDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID 0000-0001-5681-3455
Antonio PirallaMicrobiology and Virology Unit, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-6062-2579
AMCLI-GLIViRe Working Group
Funding
European Union PE00000007
6 · The paper itself
Abstract
backgroundHuman metapneumovirus (hMPV) infections have a significant impact on public health. However, the extent of this burden in Italy remains poorly defined due to a lack of comprehensive data. The aim of this cross-sectional multicenter study was to understand the epidemiology of hMPV in Italy, particularly in older adults.
methodsWe analyzed laboratory data from molecular respiratory viral diagnostic tests conducted at 17 centers across Italy from September 2022 to August 2024. Respiratory viruses were tested from outpatients for epidemiologic surveillance and from patients presenting to tertiary hospitals for diagnostic purpose. G gene sequencing was performed on a limited number of circulating strains.
resultsData from 96 460 tests yielded an overall hMPV positivity rate of 3.4%; the hMPV positivity rate was 2.6% in adults aged 50 years and older, a third of whom were aged >80 years. In north-west Italy, hMPV was detected more frequently in outpatients than in hospitalized patients. The temporal distribution of cases showed seasonal peaks in February 2023 and April 2024, which exhibited some geographic variation but overlapped in the general population and in the elderly. Phylogenetic analysis suggested an even distribution of hMPV-A and -B, with a predominance of clades A2c with a 111-nucleotide duplication and B2b, and the possible extinction of previously circulating clades A2c with a 180-nucleotide duplication and B2a.
conclusionshMPV was shown to be a relevant respiratory pathogen in older adults, who could be more likely to have severe outcomes. These findings may inform hMPV surveillance and the development of prevention strategies.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Multicenter Cross-sectional Study on the Epidemiology of Human Metapneumovirus in Italy, 2022-2024, With a Focus on Adults Over 50 Years of Age. · full record | OpenQuestion