Evidence map›Paper›PMID 40668099›Full record

ArticleThe Journal of infectious diseases2025

Clinical Features and Gene Expression Patterns in Adults Hospitalized With Respiratory Syncytial Virus and Human Metapneumovirus Infection.

Colin Samoriski, Chin-Yi Chu, Ann R Falsey, Derick Peterson, Soumyaroop Bhattacharya, Daniel P Croft, Angela R Branche, Michael Peasley, Andrea Baran, Anthony Corbett and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Biosafety and health · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Colin SamoriskiInfectious Disease Division, Department of Medicine, University of Rochester, Rochester, New York, USA.
Chin-Yi ChuDepartment of Pediatrics and Center for Children's Health Research, University of Rochester, Rochester, New York, USA.
Ann R FalseyInfectious Disease Division, Department of Medicine, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-7141-9701
Derick PetersonDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Soumyaroop BhattacharyaDepartment of Pediatrics and Center for Children's Health Research, University of Rochester, Rochester, New York, USA.ORCID 0000-0003-1140-7845
Daniel P CroftPulmonary and Critical Care Medicine Division, Department of Medicine, University of Rochester, Rochester, New York, USA.
Angela R BrancheInfectious Disease Division, Department of Medicine, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-7742-5352
Michael PeasleyInfectious Disease Division, Department of Medicine, University of Rochester, Rochester, New York, USA.
Andrea BaranDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Anthony CorbettDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
John AshtonGenomics Research Center, University of Rochester, Rochester, New York, USA.
Thomas J MarianiDepartment of Pediatrics and Center for Children's Health Research, University of Rochester, Rochester, New York, USA.
Edward E WalshInfectious Disease Division, Department of Medicine, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-8792-8877

Funding

Transcriptional Profiling to Discriminate Bacterial and Non-bacterial Respiratory IllnessesR01AI137364 · NIAID · UNIVERSITY OF ROCHESTER · PI FALSEY, ANN R, MARIANI, THOMAS J · 2019 to 2023
$3.8M
Reduction of Uneccessary Antibiotics in Adults by the Use of Viral DiagnosticsR01AI079446 · NIAID · UNIVERSITY OF ROCHESTER · PI FALSEY, ANN R · 2008 to 2011
$1.8M
Effect of Air Pollution on the Immune Response to Respiratory Viral Infection in AdultsK23ES032459 · NIEHS · UNIVERSITY OF ROCHESTER · PI CROFT, DANIEL PATRICK · 2021 to 2025
$1.2M
AstraZenecaNational Institute of Allergy and Infectious Diseases R01AI079446National Institute of Allergy and Infectious Diseases R01AI137364NIAID NIH HHS R01 AI079446NIAID NIH HHS R01 AI137364NIEHS NIH HHS K23 ES032459NIH HHS
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause acute respiratory infections (ARI) in persons of all ages. The viruses are structurally similar although HMPV lacks 2 nonstructural proteins of RSV known to suppress interferon signaling.

methodsWe analyzed data from 2 studies that prospectively enrolled hospitalized adults with ARI and compared clinical characteristics and outcomes of HMPV and RSV infection. Gene expression was compared between subjects with HMPV and RSV using DESeq2 to analyze read counts from samples of globin-reduced RNA from whole blood, sequenced using Illumina NovaSeq.

resultsOf 1914 illnesses evaluated, 127 (6.6%) had RSV and 90 (4.7%) had HMPV identified as a sole viral pathogen. Demographics and preexisting conditions were similar although HMPV patients had significantly less active tobacco use and numerically less underlying heart and lung disease. Sore throat, temperature >38°C, and clinically adjudicated pneumonia were significantly more frequent with HMPV compared to RSV. Restricting analysis to those subjects adjudicated as viral alone without bacterial coinfection, we identified 197 differentially expressed genes between RSV- and HMPV-infected subjects. Genes with higher expression in HMPV-infected individuals were associated with antigen binding, immunoglobulin production, and adaptive immunity. Genes increased in RSV-infected individuals were associated with NK T cells.

conclusionsAlthough RSV and HMPV are closely related viruses, we found differences in the clinical features of adults with HMPV patients presenting with more flu-like symptoms and viral pneumonia. Peripheral blood gene expression of hospitalized HMPV-infected patients also differed compared to those hospitalized and infected with RSV.

Indexed as

MetapneumovirusParamyxoviridae InfectionsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsAdultAgedFemaleGene Expression ProfilingHospitalizationHumansMaleMiddle AgedProspective Studiesadultsclinical featuresgene expressionHMPVRSV

Identifiers

PMID40668099
PMCPMC12265063

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.