ArticlePain2025
Androgen levels and experimental pain sensitivity in healthy young adolescent girls.
Article in Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study.Pain reports · 2026Article
- Social Relationships and Experimental Pain Sensitivity in Healthy Adolescent Girls: An Exploratory Preliminary Study.European journal of pain (London, England) · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
abstractAndrogens, such as testosterone, have an antinociceptive effect based on animal and adult studies. However, because androgens may exert different physiological effects during puberty, it is not clear whether the antinociceptive effect would also be found in adolescents. Thus, this study examined the relationships between testosterone levels and experimental pain sensitivity in healthy young adolescent girls. In addition, the relationships between experimental pain sensitivity and other androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), dihydrotestosterone, and androstenedione, were explored, and the role of puberty in moderating these relationships was tested. Forty-five healthy girls (11.91 ± 1.35 years) completed comprehensive psychophysical assessments of heat, cold, and pressure pain thresholds, heat and cold pain intensity ratings, temporal summation, heat- and pressure-conditioned pain modulation, offset analgesia, and cold pain tolerance. Blood samples were collected to analyze sex hormone levels. Participants also completed the Pubertal Developmental Scale. Correlations and regression models examined the associations between androgens and experimental pain sensitivity, and whether pubertal stage moderated these relationships. Overall, no significant associations were found between levels of testosterone, DHEA, DHEA-S, dihydrotestosterone, or androstenedione and experimental pain sensitivity, nor were these associations moderated by pubertal stage. Only DHEA-S levels were related to cold pain threshold and tolerance, and pubertal stage moderated the relationship between DHEA-S and cold pain tolerance, which was significant only in the late ( r = 0.453, P = 0.027) but not early-mid puberty group. The results of this study suggest that androgens may have a minimal effect on experimental pain sensitivity in healthy young adolescent girls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.