ArticleACS applied bio materials2025
Biomimetic Model for Electromagnetic Modulation of Cardiovascular Cellular Interactions On-Chip.
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Recent Developments, Applications, and Future Prospects of Advanced Hearts-on-a-Chip.Micromachines · 2026Review
- Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering.Journal of materials chemistry. B · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases are the leading cause of global mortality. These conditions are associated with cardiac cell death and loss of vascularization, potentially progressing to fatal myocardial infarction. However, the lack of accurate models to simulate the complex cardiac tissue microenvironment and explore alternative therapeutics contributes to heart disease still being regarded as irreversible. In this work, we developed a unique organ-on-chip platform that integrates electrical, magnetic, and mechanical stimulation to replicate the cardiac microenvironment and investigate the impact of electrical and magnetic stimulation on cardiac cell fate. Our micromodel integrated triple stimulating inputs using hybrid stimuli-responsive materials. Electromagnetic scaffolds were obtained by coating with conductive poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) electrospun coaxial fibers comprising a polycaprolactone (PCL) shell and a core of gelatin embedded with iron oxide nanoparticles (MNPs). These scaffolds were incorporated in the chip, and the properties and biological effects of these aligned electromagnetic fibers were compared with those of PEDOT:PSS-coated gelatin hydrogels with aligned magnetic particles. In the presence of an external magnetic field, both materials became more hydrophilic. PEDOT:PSS coaxial fibers demonstrated higher electroconductivity (7.9 S·cm
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Registered trials
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