Evidence map›Paper›PMID 40667755›Full record

ArticleACS sensors2025

Constant Temperature Electrochemical Biosensor for SNP Detection in Human Genomic DNA Based on DNA Melting Analysis.

Skomantas Serapinas, Deimantė Stakelytė, Kornelija Tučinskytė, Miglė Tomkuvienė, Marius Dagys, Dalius Ratautas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Skomantas SerapinasInstitute of Biochemistry, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.
Deimantė StakelytėInstitute of Biochemistry, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.
Kornelija TučinskytėInstitute of Biotechnology, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.
Miglė TomkuvienėInstitute of Biotechnology, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.
Marius DagysInstitute of Biochemistry, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.
Dalius RatautasInstitute of Biochemistry, Life Science Center, Vilnius University, Saulėtekio al. 7, LT-10224 Vilnius, Lithuania.ORCID 0000-0003-3938-3574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detection of single-nucleotide polymorphisms (SNPs) is critical in both bioanalytical science and clinical diagnostics. We present an electrochemical biosensor capable of SNP detection in human genomic DNA immediately following a polymerase chain reaction, eliminating the need for temperature gradients. The biosensor employs a "sandwich" hybridization format in which a target DNA strand binds to an electrode-anchored probe and is interrogated by two allele-specific reporters. By analyzing the kinetic differences in melting rates (

Indexed as

Biosensing TechniquesDNAElectrochemical TechniquesGenome, HumanPolymorphism, Single NucleotideTemperatureCytochrome P-450 CYP2C19HumansNucleic Acid DenaturationSalivaCytochrome P-450 CYP2C19DNAbiosensorCYP2C19goldmeltingsingle-nucleotide polymorphism

Identifiers

PMID40667755
PMCPMC12481571

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.