Evidence map›Paper›PMID 40667687›Full record

ReviewFuture medicinal chemistry2025

The current landscape of indole hybrids with

He Ling, Zhu Congcong

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

He LingDepartment of Radiation and Medical Oncology, Central Hospital of Xianning City, The First Affiliated Hospital, Hubei College of Science and Technology, Xianning, Hubei, China.
Zhu CongcongDepartment of Cardiology, The First People's Hospital of Jiangxia District, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer has emerged as a major cause of death throughout the world, leading to around 10 million deaths annually. Anticancer therapeutics play a pivotal role in cancer therapy, but they fail to fully meet the escalating, diverse, and critical needs of patients, underscoring the urgent need for innovative anticancer chemotherapeutics. Indole hybrids can simultaneously modulate multiple targets within cancer cells, potentially addressing drug resistance and adverse events associated with single-component therapies while enhancing therapeutic efficacy and improving pharmacokinetic properties. Diverse indole hybrids, including indole-azoles, indole-chalcones, indole-sulfonamides, indole-sulfones, indole-ureas, and indole-hydrazides, have been designed, synthesized, and evaluated for their

Indexed as

Antineoplastic AgentsIndolesNeoplasmsAnimalsCell ProliferationHumansMolecular StructureAntineoplastic AgentsindoleIndoleshybrid moleculesIndolein vivotherapeutic applicationstumor

Identifiers

PMID40667687
PMCPMC12296097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.