Evidence map›Paper›PMID 40667567›Full record

ArticleJCO oncology advances2025

Increasing Cervical Cancer Rates Among Women Age 35-54 Years in Canada: Age-Specific Cervical Cancer Incidence Trends in Canada, 1992-2022.

Ioana A Nicolau, Matthew T Warkentin, Kirk Graff, Corinne Doll, Heather Bryant, Darren R Brenner

Abstract read
In one paragraph

Article in JCO oncology advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioana A NicolauDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Matthew T WarkentinDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0001-8730-3511
Kirk GraffDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0001-7083-7904
Corinne DollDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0003-3595-857X
Heather BryantDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0009-0004-8042-2410
Darren R BrennerDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0002-3027-290X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe vast majority of cervical cancer is preventable through human papillomavirus vaccination and screening with cytology or DNA testing. After decades of progress, recent cervical cancer trends in Western populations show a plateau or modest increase in incidence rates. Further investigation is required to understand the drivers of these emerging trends. In this study, we examined age-specific cervical cancer incidence rates in Canada from 1992 to 2022.

methodsData were obtained from the Canadian Cancer Registry maintained by Statistics Canada, which included cancer cases, population counts, and incidence rates of cervical cancer by age and province for the period 1992 to 2022. Joinpoint regression analysis was used to estimate temporal incidence trends across age groups.

resultsCervical cancer incidence rates in Canada decreased among women age 25-34 years and those 65 years and older since 1992. Incidence rates among women age 35-44 years and 45-54 years have increased by 1.1% (95% CI, 0.5 to 2.5) and 1.6% (95% CI, -0.1 to 8.6) per year since 2001 and 2012, respectively. In 2022, the highest incidence rate of cervical cancer was among women age 35-44 years (18.1 per 100,000 women), which is comparable with rates in 1992.

conclusionCervical cancer incidence rates have been increasing in recent years among women age 35-54 years. This cohort may be falling into a cancer prevention gap. Targeted public health interventions are warranted to address the rising incidence of cervical cancer among this cohort of Canadian women.

Identifiers

PMID40667567
PMCPMC12258797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.