ArticleAmerican journal of cancer research2025
Exploring the role of YES1 kinase in regulating cisplatin resistance through iTRAQ-based quantitative proteomic analysis in urothelial carcinoma.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Urothelial carcinoma (UC) is a highly metastatic cancer that frequently develops resistance to platinum-based chemotherapy, although the underlying mechanisms remain unclear. While certain genes have been implicated in UC drug resistance, their specific roles require further validation. In this study, we established a cisplatin-resistant UC cell line (BFTC909 Cis-R) and used iTRAQ analysis to compare differences in protein expression between BFTC909 Cis-R cells and their parental BFTC909 counterparts. iTRAQ mass analysis revealed decreased expression of the tyrosine kinase YES1 in BFTC909 Cis-R cells, along with reduced levels of YES1 and YAP in both BFTC909 Cis-R and T24 Cis-R cells. Moreover, we found that bladder cancer patients with higher YES1 expression had significantly better survival outcomes in our in-house cohort and two public datasets (GSE13507 and GSE169455). Treatment with dasatinib, a YES1 inhibitor, reduced cisplatin-induced cytotoxicity in UMUC-14 cells, suggesting that YES1 influences cisplatin efficacy in UC cells. Our findings indicate that YES1 plays a critical role in cisplatin resistance and may represent a promising therapeutic target in bladder cancer.
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