Evidence map›Paper›PMID 40667545›Full record

ArticleAmerican journal of cancer research2025

Enhanced inhibitory effects of mianserin in combination with sorafenib on liver cancer growth through targeting the CCR9-AKT pathway.

Ya-Hui Huang, Chia-Jung Liao, Meng-Han Wu, Ming-Wei Lai, Yung-Hsin Yeh, Chau-Ting Yeh, Yang-Hsiang Lin, Kwang-Huei Lin

Abstract read
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ya-Hui HuangLiver Research Center, Chang Gung Memorial Hospital, Linkou Main Branch Taoyuan, Taiwan.
Chia-Jung LiaoGraduate Institute of Biomedical Sciences, College of Medicine, Chang-Gung University Taoyuan, Taiwan.
Meng-Han WuGraduate Institute of Biomedical Sciences, College of Medicine, Chang-Gung University Taoyuan, Taiwan.
Ming-Wei LaiLiver Research Center, Chang Gung Memorial Hospital, Linkou Main Branch Taoyuan, Taiwan.
Yung-Hsin YehDepartment of Cardiovascular, Chang-Gung Memorial Hospital Tao-Yuan, Taiwan.
Chau-Ting YehLiver Research Center, Chang Gung Memorial Hospital, Linkou Main Branch Taoyuan, Taiwan.
Yang-Hsiang LinLiver Research Center, Chang Gung Memorial Hospital, Linkou Main Branch Taoyuan, Taiwan.
Kwang-Huei LinLiver Research Center, Chang Gung Memorial Hospital, Linkou Main Branch Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, our group showed that mianserin, an atypical antidepressant, exerts stronger cytotoxicity against liver cancer cells than normal hepatocytes, supporting its potential application as a therapeutic agent for liver cancer. However, the anti-tumor effects of mianserin

Indexed as

AKTCCR9HSP60Liver cancermianserinsorafenib

Identifiers

PMID40667545
PMCPMC12256417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.