Evidence map›Paper›PMID 40667505›Full record

ReviewFrontiers in pharmacology2025

Clinical characterization and management of persons with comorbid epilepsy and depression: an expert opinion paper.

Gaia Sampogna, Roberto Brugnoli, Giuseppe Didato, Maurizio Elia, Edoardo Ferlazzo, Gianluca Serafini, Giampaolo Vatti, Umberto Volpe, Flavio Villani, Gabriele Sani

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Epilepsy grand challenge 2025.Frontiers in neurology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gaia SampognaDepartment of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
Roberto BrugnoliDepartment of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Giuseppe DidatoEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Maurizio EliaOasi Research Institute-IRCCS, Troina, Italy.
Edoardo FerlazzoDepartment of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Gianluca SerafiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy.
Giampaolo VattiUnità Operativa Complessa Neurology and Clinical Neurophysiology, University Hospital of Siena, Siena, Italy.
Umberto VolpeDivision of Clinical Neurophysiology and Epilepsy Center, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Martino, Genoa, Italy.
Flavio VillaniUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy.
Gabriele SaniDepartment of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Medical conditions related to the nervous system affects 3.4 billion individuals worldwide and are collectively ranked as the leading cause of disability-adjusted life years (DALYs). Epilepsy is listed among the ten conditions with the highest age standardized DALYs, while depression is expected to become the first cause of disability for mental disorders by 2030. Persons with epilepsy have a higher risk of developing depression, and Methods: The present mini-review is based on expert meetings held in the period May-September 2024. A panel of expert clinicians, working in the field of epilepsy and of clinical psychiatry have been invited to participate, due to their experience and expertise in the topic. Panel members, under the guidance of two senior experts, have identified the relevant topics to be analyzed, discussed and commented. Results: Included studies dealt with the historical perspective on epilepsy and depression; the complexity of diagnostic and clinical comorbidity between epilepsy and depression; the assessment tools for screening for depression in patients with epilepsy. Discussion: The clinical condition of patients suffering from comorbid depression and epilepsy represents a challenge for neurologists and psychiatrists. Therefore, the management of comorbid epilepsy and depression requires a detailed clinical characterization of each individual case in order to develop an integrated and personalized management plan.

Indexed as

burdencomorbiditydepressiondifferential diagnosisepilepsy

Identifiers

PMID40667505
PMCPMC12259570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.