Inverse association between dietary fiber intake and gallstone disease in U.S. adults: a cross-sectional study from the NHANES database.

Background: The cross-sectional association of dietary fiber intake with gallstone disease in United States adults remains to be comprehensively elucidated. Methods: We used the National Health and Nutrition Examination Survey (NHANES) data from 2017-2023. The assessment of dietary fiber intake was derived from 24-h dietary recalls. Stratified analyses were then used to demonstrate dietary fiber intake corresponding to different groups of gallstone and non-gallstone conditions. The use of weighted logistic regression was employed to explore the correlation between dietary fiber intake and gallstone disease. Subgroup and interaction analyses were used to identify potential interacting factors. Additionally, restricted cubic spline was used to assess the dose-response between dietary fiber and gallstone risk. Results: The study population comprised 9,273 patients, with a gallstone prevalence of 10.47% (971 cases). In the context of various subgroups, patients diagnosed with gallstones exhibited a reduced dietary fiber intake in comparison with individuals not bearing gallstones. In the fully adjusted model, an inverse association was observed between dietary fiber intake and gallstone disease (odds ratio (OR), 95% confidence interval (CI); 0.98 (0.96,1.00), Conclusion: Dietary fiber intake is inversely associated with gallstone disease in United States adults. Adequate dietary fiber intake may be beneficial in reducing gallstone prevalence.